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Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages

DCDC2 is a gene strongly associated with components of the phonological processing system in animal models and in multiple independent studies of populations and languages. We propose that it may also influence population-level variation in language component usage. To test this hypothesis, we inves...

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Autores principales: DeMille, Mellissa M. C., Tang, Kevin, Mehta, Chintan M., Geissler, Christopher, Malins, Jeffrey G., Powers, Natalie R., Bowen, Beatrice M., Adams, Andrew K., Truong, Dongnhu T., Frijters, Jan C., Gruen, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948951/
https://www.ncbi.nlm.nih.gov/pubmed/29666269
http://dx.doi.org/10.1073/pnas.1710472115
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author DeMille, Mellissa M. C.
Tang, Kevin
Mehta, Chintan M.
Geissler, Christopher
Malins, Jeffrey G.
Powers, Natalie R.
Bowen, Beatrice M.
Adams, Andrew K.
Truong, Dongnhu T.
Frijters, Jan C.
Gruen, Jeffrey R.
author_facet DeMille, Mellissa M. C.
Tang, Kevin
Mehta, Chintan M.
Geissler, Christopher
Malins, Jeffrey G.
Powers, Natalie R.
Bowen, Beatrice M.
Adams, Andrew K.
Truong, Dongnhu T.
Frijters, Jan C.
Gruen, Jeffrey R.
author_sort DeMille, Mellissa M. C.
collection PubMed
description DCDC2 is a gene strongly associated with components of the phonological processing system in animal models and in multiple independent studies of populations and languages. We propose that it may also influence population-level variation in language component usage. To test this hypothesis, we investigated the evolution and worldwide distribution of the READ1 regulatory element within DCDC2, and compared its distribution with variation in different language properties. The mutational history of READ1 was estimated by examining primate and archaic hominin sequences. This identified duplication and expansion events, which created a large number of polymorphic alleles based on internal repeat units (RU1 and RU2). Association of READ1 alleles was studied with respect to the numbers of consonants and vowels for languages in 43 human populations distributed across five continents. Using population-based approaches with multivariate ANCOVA and linear mixed effects analyses, we found that the RU1-1 allele group of READ1 is significantly associated with the number of consonants within languages independent of genetic relatedness, geographic proximity, and language family. We propose that allelic variation in READ1 helped create a subtle cognitive bias that was amplified by cultural transmission, and ultimately shaped consonant use by different populations over time.
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spelling pubmed-59489512018-05-14 Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages DeMille, Mellissa M. C. Tang, Kevin Mehta, Chintan M. Geissler, Christopher Malins, Jeffrey G. Powers, Natalie R. Bowen, Beatrice M. Adams, Andrew K. Truong, Dongnhu T. Frijters, Jan C. Gruen, Jeffrey R. Proc Natl Acad Sci U S A Biological Sciences DCDC2 is a gene strongly associated with components of the phonological processing system in animal models and in multiple independent studies of populations and languages. We propose that it may also influence population-level variation in language component usage. To test this hypothesis, we investigated the evolution and worldwide distribution of the READ1 regulatory element within DCDC2, and compared its distribution with variation in different language properties. The mutational history of READ1 was estimated by examining primate and archaic hominin sequences. This identified duplication and expansion events, which created a large number of polymorphic alleles based on internal repeat units (RU1 and RU2). Association of READ1 alleles was studied with respect to the numbers of consonants and vowels for languages in 43 human populations distributed across five continents. Using population-based approaches with multivariate ANCOVA and linear mixed effects analyses, we found that the RU1-1 allele group of READ1 is significantly associated with the number of consonants within languages independent of genetic relatedness, geographic proximity, and language family. We propose that allelic variation in READ1 helped create a subtle cognitive bias that was amplified by cultural transmission, and ultimately shaped consonant use by different populations over time. National Academy of Sciences 2018-05-08 2018-04-16 /pmc/articles/PMC5948951/ /pubmed/29666269 http://dx.doi.org/10.1073/pnas.1710472115 Text en Copyright © 2018 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
DeMille, Mellissa M. C.
Tang, Kevin
Mehta, Chintan M.
Geissler, Christopher
Malins, Jeffrey G.
Powers, Natalie R.
Bowen, Beatrice M.
Adams, Andrew K.
Truong, Dongnhu T.
Frijters, Jan C.
Gruen, Jeffrey R.
Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
title Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
title_full Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
title_fullStr Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
title_full_unstemmed Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
title_short Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
title_sort worldwide distribution of the dcdc2 read1 regulatory element and its relationship with phoneme variation across languages
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948951/
https://www.ncbi.nlm.nih.gov/pubmed/29666269
http://dx.doi.org/10.1073/pnas.1710472115
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