Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

Effective and safe delivery of the CRISPR/Cas9 gene-editing elements remains a challenge. Here we report the development of PEGylated nanoparticles (named P-HNPs) based on the cationic α-helical polypeptide poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) for the delivery of Cas9 e...

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Detalles Bibliográficos
Autores principales: Wang, Hong-Xia, Song, Ziyuan, Lao, Yeh-Hsing, Xu, Xin, Gong, Jing, Cheng, Du, Chakraborty, Syandan, Park, Ji Sun, Li, Mingqiang, Huang, Dantong, Yin, Lichen, Cheng, Jianjun, Leong, Kam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948953/
https://www.ncbi.nlm.nih.gov/pubmed/29686087
http://dx.doi.org/10.1073/pnas.1712963115

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