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Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice

Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of...

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Autores principales: Nieoczym, Dorota, Socała, Katarzyna, Wlaź, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949134/
https://www.ncbi.nlm.nih.gov/pubmed/29541930
http://dx.doi.org/10.1007/s11064-018-2505-z
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author Nieoczym, Dorota
Socała, Katarzyna
Wlaź, Piotr
author_facet Nieoczym, Dorota
Socała, Katarzyna
Wlaź, Piotr
author_sort Nieoczym, Dorota
collection PubMed
description Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervous system-related processes, i.e., pain, anxiety and depression, was proved in experimental studies. UA also revealed anticonvulsant properties in animal models of epilepsy and seizures. The aim of the present study was to investigate the influence of UA on seizure thresholds in three acute seizure models in mice, i.e., the 6 Hz-induced psychomotor seizure threshold test, the maximal electroshock threshold (MEST) test and the timed intravenous pentylenetetrazole (iv PTZ) infusion test. We also examined its effect on the muscular strength (assessed in the grip strength test) and motor coordination (estimated in the chimney test) in mice. UA at doses of 50 and 100 mg/kg significantly increased the seizure thresholds in the 6 Hz and MEST tests. The studied compound did not influence the seizure thresholds in the iv PTZ test. Moreover, UA did not affect the motor coordination and muscular strength in mice. UA displays only a weak anticonvulsant potential which is dependent on the used seizure model.
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spelling pubmed-59491342018-05-17 Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice Nieoczym, Dorota Socała, Katarzyna Wlaź, Piotr Neurochem Res Original Paper Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervous system-related processes, i.e., pain, anxiety and depression, was proved in experimental studies. UA also revealed anticonvulsant properties in animal models of epilepsy and seizures. The aim of the present study was to investigate the influence of UA on seizure thresholds in three acute seizure models in mice, i.e., the 6 Hz-induced psychomotor seizure threshold test, the maximal electroshock threshold (MEST) test and the timed intravenous pentylenetetrazole (iv PTZ) infusion test. We also examined its effect on the muscular strength (assessed in the grip strength test) and motor coordination (estimated in the chimney test) in mice. UA at doses of 50 and 100 mg/kg significantly increased the seizure thresholds in the 6 Hz and MEST tests. The studied compound did not influence the seizure thresholds in the iv PTZ test. Moreover, UA did not affect the motor coordination and muscular strength in mice. UA displays only a weak anticonvulsant potential which is dependent on the used seizure model. Springer US 2018-03-14 2018 /pmc/articles/PMC5949134/ /pubmed/29541930 http://dx.doi.org/10.1007/s11064-018-2505-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Nieoczym, Dorota
Socała, Katarzyna
Wlaź, Piotr
Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
title Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
title_full Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
title_fullStr Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
title_full_unstemmed Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
title_short Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
title_sort assessment of the anticonvulsant potency of ursolic acid in seizure threshold tests in mice
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949134/
https://www.ncbi.nlm.nih.gov/pubmed/29541930
http://dx.doi.org/10.1007/s11064-018-2505-z
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