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Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans

Candida albicans is the most common fungal pathogen causing serious diseases, while there are only a paucity of antifungal drugs. Therefore, the present study was performed to investigate the antifungal effects of saponin extract from rhizomes of Dioscorea panthaica Prain et Burk (Huangshanyao Sapon...

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Autores principales: Yang, Longfei, Liu, Xin, Zhuang, Xinming, Feng, Xuechao, Zhong, Lili, Ma, Tonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949152/
https://www.ncbi.nlm.nih.gov/pubmed/29853962
http://dx.doi.org/10.1155/2018/6095307
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author Yang, Longfei
Liu, Xin
Zhuang, Xinming
Feng, Xuechao
Zhong, Lili
Ma, Tonghui
author_facet Yang, Longfei
Liu, Xin
Zhuang, Xinming
Feng, Xuechao
Zhong, Lili
Ma, Tonghui
author_sort Yang, Longfei
collection PubMed
description Candida albicans is the most common fungal pathogen causing serious diseases, while there are only a paucity of antifungal drugs. Therefore, the present study was performed to investigate the antifungal effects of saponin extract from rhizomes of Dioscorea panthaica Prain et Burk (Huangshanyao Saponin extract, HSE) against C. albicans. HSE inhibits the planktonic growth and biofilm formation and development of C. albicans. 16–64 μg/mL of HSE could inhibit adhesion to polystyrene surfaces, transition from yeast to filamentous growth, and production of secreted phospholipase and could also induce endogenous reactive oxygen species (ROS) production and disrupt cell membrane in planktonic cells. Inhibitory activities against extracellular exopolysaccharide (EPS) production and ROS production in preformed biofilms could be inhibited by 64–256 μg/mL of HSE. Cytotoxicity against human Chang's liver cells is low, with a half maximal inhibitory concentration (IC(50)) of about 256 μg/mL. In sum, our study suggested that HSE might be used as a potential antifungal therapeutic against C. albicans.
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spelling pubmed-59491522018-05-31 Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans Yang, Longfei Liu, Xin Zhuang, Xinming Feng, Xuechao Zhong, Lili Ma, Tonghui Evid Based Complement Alternat Med Research Article Candida albicans is the most common fungal pathogen causing serious diseases, while there are only a paucity of antifungal drugs. Therefore, the present study was performed to investigate the antifungal effects of saponin extract from rhizomes of Dioscorea panthaica Prain et Burk (Huangshanyao Saponin extract, HSE) against C. albicans. HSE inhibits the planktonic growth and biofilm formation and development of C. albicans. 16–64 μg/mL of HSE could inhibit adhesion to polystyrene surfaces, transition from yeast to filamentous growth, and production of secreted phospholipase and could also induce endogenous reactive oxygen species (ROS) production and disrupt cell membrane in planktonic cells. Inhibitory activities against extracellular exopolysaccharide (EPS) production and ROS production in preformed biofilms could be inhibited by 64–256 μg/mL of HSE. Cytotoxicity against human Chang's liver cells is low, with a half maximal inhibitory concentration (IC(50)) of about 256 μg/mL. In sum, our study suggested that HSE might be used as a potential antifungal therapeutic against C. albicans. Hindawi 2018-04-29 /pmc/articles/PMC5949152/ /pubmed/29853962 http://dx.doi.org/10.1155/2018/6095307 Text en Copyright © 2018 Longfei Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Longfei
Liu, Xin
Zhuang, Xinming
Feng, Xuechao
Zhong, Lili
Ma, Tonghui
Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
title Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
title_full Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
title_fullStr Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
title_full_unstemmed Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
title_short Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
title_sort antifungal effects of saponin extract from rhizomes of dioscorea panthaica prain et burk against candida albicans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949152/
https://www.ncbi.nlm.nih.gov/pubmed/29853962
http://dx.doi.org/10.1155/2018/6095307
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