Rho kinase and Na(+)/H(+) exchanger mediate endothelin‐1‐induced pulmonary arterial smooth muscle cell proliferation and migration

Excessive production of endothelin‐1 (ET‐1) has been observed in almost all forms of pulmonary hypertension. ET‐1, a highly potent vasoconstrictor, can also potentiate pulmonary arterial smooth muscle cell (PASMC) growth and migration, both of which contribute to the vascular remodeling that occurs...

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Detalles Bibliográficos
Autores principales: Huetsch, John C., Walker, Jasmine, Undem, Clark, Lade, Julie, Yun, Xin, Baksh, Syeda, Jiang, Haiyang, Lai, Ning, Shimoda, Larissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949284/
https://www.ncbi.nlm.nih.gov/pubmed/29756391
http://dx.doi.org/10.14814/phy2.13698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949284/
https://www.ncbi.nlm.nih.gov/pubmed/29756391
http://dx.doi.org/10.14814/phy2.13698

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