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Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis

PURPOSE: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made se...

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Autores principales: Kim, Ji Suk, Pak, Kyoungjune, Goh, Tae Sik, Jeong, Dae Cheon, Han, Myoung-Eun, Kim, Jihyun, Oh, Sae-Ock, Kim, Chi Dae, Kim, Yun Hak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949291/
https://www.ncbi.nlm.nih.gov/pubmed/29749132
http://dx.doi.org/10.3349/ymj.2018.59.4.495
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author Kim, Ji Suk
Pak, Kyoungjune
Goh, Tae Sik
Jeong, Dae Cheon
Han, Myoung-Eun
Kim, Jihyun
Oh, Sae-Ock
Kim, Chi Dae
Kim, Yun Hak
author_facet Kim, Ji Suk
Pak, Kyoungjune
Goh, Tae Sik
Jeong, Dae Cheon
Han, Myoung-Eun
Kim, Jihyun
Oh, Sae-Ock
Kim, Chi Dae
Kim, Yun Hak
author_sort Kim, Ji Suk
collection PubMed
description PURPOSE: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications. Studies of CADs with results on miRNAs that reported survival data or MACEs were included. Data were extracted from each publication independently by two reviewers. RESULTS: After reviewing 515 articles, a total eight studies were included in this study. We measured pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miRNA 133a with a fixed-effect model (pooled HR, 2.35; 95% CI, 1.56–3.55). High expression of miRNA 133a, 208b, 126, 197, 223, and 122-5p were associated with high mortality. Additionally, high levels of miRNA 208b, 499-5p, 134, 328, and 34a were related with MACEs. CONCLUSION: The present study confirmed that miRNA 133a, which was associated with high mortality in CAD patients, holds prognostic value in CAD. More importantly, this study corrected issues raised against a prior meta-analysis and provides accurate information.
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spelling pubmed-59492912018-06-01 Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis Kim, Ji Suk Pak, Kyoungjune Goh, Tae Sik Jeong, Dae Cheon Han, Myoung-Eun Kim, Jihyun Oh, Sae-Ock Kim, Chi Dae Kim, Yun Hak Yonsei Med J Original Article PURPOSE: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications. Studies of CADs with results on miRNAs that reported survival data or MACEs were included. Data were extracted from each publication independently by two reviewers. RESULTS: After reviewing 515 articles, a total eight studies were included in this study. We measured pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miRNA 133a with a fixed-effect model (pooled HR, 2.35; 95% CI, 1.56–3.55). High expression of miRNA 133a, 208b, 126, 197, 223, and 122-5p were associated with high mortality. Additionally, high levels of miRNA 208b, 499-5p, 134, 328, and 34a were related with MACEs. CONCLUSION: The present study confirmed that miRNA 133a, which was associated with high mortality in CAD patients, holds prognostic value in CAD. More importantly, this study corrected issues raised against a prior meta-analysis and provides accurate information. Yonsei University College of Medicine 2018-06-01 2018-05-03 /pmc/articles/PMC5949291/ /pubmed/29749132 http://dx.doi.org/10.3349/ymj.2018.59.4.495 Text en © Copyright: Yonsei University College of Medicine 2018 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Ji Suk
Pak, Kyoungjune
Goh, Tae Sik
Jeong, Dae Cheon
Han, Myoung-Eun
Kim, Jihyun
Oh, Sae-Ock
Kim, Chi Dae
Kim, Yun Hak
Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis
title Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis
title_full Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis
title_fullStr Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis
title_full_unstemmed Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis
title_short Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis
title_sort prognostic value of micrornas in coronary artery diseases: a meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949291/
https://www.ncbi.nlm.nih.gov/pubmed/29749132
http://dx.doi.org/10.3349/ymj.2018.59.4.495
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