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Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species

Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates. In the brain, Kiss1 gene is mainly expressed in the hypothalamic region, but KissR gene is widely di...

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Autores principales: Ogawa, Satoshi, Parhar, Ishwar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949316/
https://www.ncbi.nlm.nih.gov/pubmed/29867758
http://dx.doi.org/10.3389/fendo.2018.00222
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author Ogawa, Satoshi
Parhar, Ishwar S.
author_facet Ogawa, Satoshi
Parhar, Ishwar S.
author_sort Ogawa, Satoshi
collection PubMed
description Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates. In the brain, Kiss1 gene is mainly expressed in the hypothalamic region, but KissR gene is widely distributed throughout the brain, suggesting that kisspeptin–KissR system may be involved in not only reproductive, but also non-reproductive functions. In non-mammalian vertebrates, there are two or more kisspeptin and KissR types. The zebrafish (Danio rerio) possess two kisspeptin (Kiss1 and Kiss2) and their respective receptors [Kiss1 receptor (KissR1) and KissR2]. In the brain of zebrafish, while Kiss2 is expressed in the preoptic-hypothalamic area, Kiss1 is predominantly expressed in the habenula, an evolutionarily conserved epithalamic structure. Similarly, KissR1 is expressed only in the habenula, while KissR2 is widely distributed in the brain, suggesting that the two kisspeptin systems play specific roles in the brain. The habenular Kiss1 is involved in the modulation of the raphe nuclei and serotonin-related behaviors such as fear response in the zebrafish. This review summarizes the roles of multiple kisspeptin–KissR systems in reproductive and non-reproductive functions and neuronal mechanism, and debates the biological and evolutional significance of habenular kisspeptin–KissR systems in teleost species.
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spelling pubmed-59493162018-06-04 Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species Ogawa, Satoshi Parhar, Ishwar S. Front Endocrinol (Lausanne) Endocrinology Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates. In the brain, Kiss1 gene is mainly expressed in the hypothalamic region, but KissR gene is widely distributed throughout the brain, suggesting that kisspeptin–KissR system may be involved in not only reproductive, but also non-reproductive functions. In non-mammalian vertebrates, there are two or more kisspeptin and KissR types. The zebrafish (Danio rerio) possess two kisspeptin (Kiss1 and Kiss2) and their respective receptors [Kiss1 receptor (KissR1) and KissR2]. In the brain of zebrafish, while Kiss2 is expressed in the preoptic-hypothalamic area, Kiss1 is predominantly expressed in the habenula, an evolutionarily conserved epithalamic structure. Similarly, KissR1 is expressed only in the habenula, while KissR2 is widely distributed in the brain, suggesting that the two kisspeptin systems play specific roles in the brain. The habenular Kiss1 is involved in the modulation of the raphe nuclei and serotonin-related behaviors such as fear response in the zebrafish. This review summarizes the roles of multiple kisspeptin–KissR systems in reproductive and non-reproductive functions and neuronal mechanism, and debates the biological and evolutional significance of habenular kisspeptin–KissR systems in teleost species. Frontiers Media S.A. 2018-05-07 /pmc/articles/PMC5949316/ /pubmed/29867758 http://dx.doi.org/10.3389/fendo.2018.00222 Text en Copyright © 2018 Ogawa and Parhar. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ogawa, Satoshi
Parhar, Ishwar S.
Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
title Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
title_full Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
title_fullStr Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
title_full_unstemmed Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
title_short Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
title_sort biological significance of kisspeptin–kiss 1 receptor signaling in the habenula of teleost species
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949316/
https://www.ncbi.nlm.nih.gov/pubmed/29867758
http://dx.doi.org/10.3389/fendo.2018.00222
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