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Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine

BACKGROUND: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Ubiquitously expressed volume-regulated anion channels (VRAC) are thought to play a role in cell proliferation, migration, and apoptosis. VRAC are heteromeric channel complexes assembled from proteins belongin...

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Detalles Bibliográficos
Autores principales:	Rubino, Sebastian, Bach, Martin D., Schober, Alexandra L., Lambert, Ian H., Mongin, Alexander A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949383/ https://www.ncbi.nlm.nih.gov/pubmed/29868469 http://dx.doi.org/10.3389/fonc.2018.00142

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