Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects

Interferon regulatory factor 5 (IRF5) is widely recognized as a risk locus for systemic lupus erythematosus (SLE). Risk gene and IRF5 activation is triggered through toll-like receptor signaling. In myeloid cells, this leads to production of type I interferon and inflammatory cytokines, with enhance...

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Detalles Bibliográficos
Autores principales: Calise, Justine, Marquez Renteria, Susana, Gregersen, Peter K., Diamond, Betty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949527/
https://www.ncbi.nlm.nih.gov/pubmed/29867973
http://dx.doi.org/10.3389/fimmu.2018.00996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949527/
https://www.ncbi.nlm.nih.gov/pubmed/29867973
http://dx.doi.org/10.3389/fimmu.2018.00996

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