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Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease

INTRODUCTION: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20–25%, and that of celiac antibodies is 2–5%. The goal of this study was to determine the prevalence of PC-A...

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Autores principales: Twito, Orit, Shapiro, Yonatan, Golan-Cohen, Aviva, Dickstein, Yoav, Ness-Abramof, Rosane, Shapiro, Menachem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949896/
https://www.ncbi.nlm.nih.gov/pubmed/29765436
http://dx.doi.org/10.5114/aoms.2016.58743
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author Twito, Orit
Shapiro, Yonatan
Golan-Cohen, Aviva
Dickstein, Yoav
Ness-Abramof, Rosane
Shapiro, Menachem
author_facet Twito, Orit
Shapiro, Yonatan
Golan-Cohen, Aviva
Dickstein, Yoav
Ness-Abramof, Rosane
Shapiro, Menachem
author_sort Twito, Orit
collection PubMed
description INTRODUCTION: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20–25%, and that of celiac antibodies is 2–5%. The goal of this study was to determine the prevalence of PC-Ab and anti-tissue transglutaminase antibodies (tTG-Ab) in patients with ATD and to evaluate the correlation between anti-thyroid antibodies and the other antibodies. MATERIAL AND METHODS: The files of 120 Israeli Jews and Arabs with ATD were evaluated for anti-thyroglobulin antibodies (Tg-Ab), anti-thyroid peroxidase antibodies (TPO-Ab), PC-Ab and tTG-Ab. For patients with positive PC-Ab and/or tTG-Ab, upper gastrointestinal (GI) endoscopy results were recorded. Gastrin levels were collected in patients with positive PC-Ab. RESULTS: Twelve (10%) males and 108 (90%) females were evaluated, of whom 93.33% had Hashimoto’s thyroiditis. Thirty-four (28.3%) subjects had positive PC-Ab. This rate was not affected by gender, ethnicity or thyroid disease. Abnormal gastroscopy findings were documented in 95.2% of the upper GI endoscopies. The mean gastrin level in this subgroup was 660.4 pg/ml. Five of 114 tTG-Ab tests were positive (4.4%). All were females with Hashimoto’s thyroiditis. Rates were equal among Jews and Arabs. Higher TPO-Ab levels were associated with higher risk for PC-Ab positivity (p = 0.027), but not tTG-positivity. Higher Tg-Ab levels were not associated with higher levels of other antibodies. CONCLUSIONS: Considering the frequency of PC-Ab and tTG-Ab positivity in ATD, checking for the presence of these two entities should be an integral part of the workup of this disease.
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spelling pubmed-59498962018-05-14 Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease Twito, Orit Shapiro, Yonatan Golan-Cohen, Aviva Dickstein, Yoav Ness-Abramof, Rosane Shapiro, Menachem Arch Med Sci Clinical Research INTRODUCTION: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20–25%, and that of celiac antibodies is 2–5%. The goal of this study was to determine the prevalence of PC-Ab and anti-tissue transglutaminase antibodies (tTG-Ab) in patients with ATD and to evaluate the correlation between anti-thyroid antibodies and the other antibodies. MATERIAL AND METHODS: The files of 120 Israeli Jews and Arabs with ATD were evaluated for anti-thyroglobulin antibodies (Tg-Ab), anti-thyroid peroxidase antibodies (TPO-Ab), PC-Ab and tTG-Ab. For patients with positive PC-Ab and/or tTG-Ab, upper gastrointestinal (GI) endoscopy results were recorded. Gastrin levels were collected in patients with positive PC-Ab. RESULTS: Twelve (10%) males and 108 (90%) females were evaluated, of whom 93.33% had Hashimoto’s thyroiditis. Thirty-four (28.3%) subjects had positive PC-Ab. This rate was not affected by gender, ethnicity or thyroid disease. Abnormal gastroscopy findings were documented in 95.2% of the upper GI endoscopies. The mean gastrin level in this subgroup was 660.4 pg/ml. Five of 114 tTG-Ab tests were positive (4.4%). All were females with Hashimoto’s thyroiditis. Rates were equal among Jews and Arabs. Higher TPO-Ab levels were associated with higher risk for PC-Ab positivity (p = 0.027), but not tTG-positivity. Higher Tg-Ab levels were not associated with higher levels of other antibodies. CONCLUSIONS: Considering the frequency of PC-Ab and tTG-Ab positivity in ATD, checking for the presence of these two entities should be an integral part of the workup of this disease. Termedia Publishing House 2016-03-23 2018-04 /pmc/articles/PMC5949896/ /pubmed/29765436 http://dx.doi.org/10.5114/aoms.2016.58743 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Twito, Orit
Shapiro, Yonatan
Golan-Cohen, Aviva
Dickstein, Yoav
Ness-Abramof, Rosane
Shapiro, Menachem
Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
title Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
title_full Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
title_fullStr Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
title_full_unstemmed Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
title_short Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
title_sort anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949896/
https://www.ncbi.nlm.nih.gov/pubmed/29765436
http://dx.doi.org/10.5114/aoms.2016.58743
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