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Epigenetic regulation of inflammation in stroke

Despite extensive research, treatments for clinical stroke are still limited only to the administration of tissue plasminogen activator and the recent introduction of mechanical thrombectomy, which can be used in only a limited proportion of patients due to time constraints. A plethora of inflammato...

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Autores principales: Ng, Gavin Yong-Quan, Yun-An, Lim, Sobey, Christopher G., Dheen, Thameem, Fann, David Yang-Wei, Arumugam, Thiruma V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949939/
https://www.ncbi.nlm.nih.gov/pubmed/29774056
http://dx.doi.org/10.1177/1756286418771815
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author Ng, Gavin Yong-Quan
Yun-An, Lim
Sobey, Christopher G.
Dheen, Thameem
Fann, David Yang-Wei
Arumugam, Thiruma V.
author_facet Ng, Gavin Yong-Quan
Yun-An, Lim
Sobey, Christopher G.
Dheen, Thameem
Fann, David Yang-Wei
Arumugam, Thiruma V.
author_sort Ng, Gavin Yong-Quan
collection PubMed
description Despite extensive research, treatments for clinical stroke are still limited only to the administration of tissue plasminogen activator and the recent introduction of mechanical thrombectomy, which can be used in only a limited proportion of patients due to time constraints. A plethora of inflammatory events occur during stroke, arising in part due to the body’s immune response to brain injury. Neuroinflammation contributes significantly to neuronal cell death and the development of functional impairment and death in stroke patients. Therefore, elucidating the molecular and cellular mechanisms underlying inflammatory damage following stroke injury will be essential for the development of useful therapies. Research findings increasingly point to the likelihood that epigenetic mechanisms play a role in the pathophysiology of stroke. Epigenetics involves the differential regulation of gene expression, including those involved in brain inflammation and remodelling after stroke. Hence, it is conceivable that epigenetic mechanisms may contribute to differential interindividual vulnerability and injury responses to cerebral ischaemia. In this review, we summarize recent findings on the emerging role of epigenetics in the regulation of neuroinflammation in stroke. We also discuss potential epigenetic targets that may be assessed for the development of stroke therapies.
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spelling pubmed-59499392018-05-17 Epigenetic regulation of inflammation in stroke Ng, Gavin Yong-Quan Yun-An, Lim Sobey, Christopher G. Dheen, Thameem Fann, David Yang-Wei Arumugam, Thiruma V. Ther Adv Neurol Disord Review Despite extensive research, treatments for clinical stroke are still limited only to the administration of tissue plasminogen activator and the recent introduction of mechanical thrombectomy, which can be used in only a limited proportion of patients due to time constraints. A plethora of inflammatory events occur during stroke, arising in part due to the body’s immune response to brain injury. Neuroinflammation contributes significantly to neuronal cell death and the development of functional impairment and death in stroke patients. Therefore, elucidating the molecular and cellular mechanisms underlying inflammatory damage following stroke injury will be essential for the development of useful therapies. Research findings increasingly point to the likelihood that epigenetic mechanisms play a role in the pathophysiology of stroke. Epigenetics involves the differential regulation of gene expression, including those involved in brain inflammation and remodelling after stroke. Hence, it is conceivable that epigenetic mechanisms may contribute to differential interindividual vulnerability and injury responses to cerebral ischaemia. In this review, we summarize recent findings on the emerging role of epigenetics in the regulation of neuroinflammation in stroke. We also discuss potential epigenetic targets that may be assessed for the development of stroke therapies. SAGE Publications 2018-04-26 /pmc/articles/PMC5949939/ /pubmed/29774056 http://dx.doi.org/10.1177/1756286418771815 Text en © The Author(s), 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Ng, Gavin Yong-Quan
Yun-An, Lim
Sobey, Christopher G.
Dheen, Thameem
Fann, David Yang-Wei
Arumugam, Thiruma V.
Epigenetic regulation of inflammation in stroke
title Epigenetic regulation of inflammation in stroke
title_full Epigenetic regulation of inflammation in stroke
title_fullStr Epigenetic regulation of inflammation in stroke
title_full_unstemmed Epigenetic regulation of inflammation in stroke
title_short Epigenetic regulation of inflammation in stroke
title_sort epigenetic regulation of inflammation in stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949939/
https://www.ncbi.nlm.nih.gov/pubmed/29774056
http://dx.doi.org/10.1177/1756286418771815
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