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Food intake attenuates the drug interaction between new quinolones and aluminum

BACKGROUND: Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food intake on the extent of drug - drug interact...

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Autores principales: Imaoka, Ayuko, Abiru, Kosuke, Akiyoshi, Takeshi, Ohtani, Hisakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950139/
https://www.ncbi.nlm.nih.gov/pubmed/29785276
http://dx.doi.org/10.1186/s40780-018-0107-1
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author Imaoka, Ayuko
Abiru, Kosuke
Akiyoshi, Takeshi
Ohtani, Hisakazu
author_facet Imaoka, Ayuko
Abiru, Kosuke
Akiyoshi, Takeshi
Ohtani, Hisakazu
author_sort Imaoka, Ayuko
collection PubMed
description BACKGROUND: Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food intake on the extent of drug - drug interaction between new quinolones and metal cations remains to be investigated quantitatively and systematically. The aim of this study was to develop an animal model that enables to evaluate the effect of food intake on the extent of drug - drug interaction in the gastrointestinal tract by chelation and to apply the model to evaluate quantitatively the effect of food intake on the drug - drug interaction between two new quinolones, ofloxacin or ciprofloxacin and sucralfate. METHODS: The rats were orally administered new quinolones (5.3 mg/kg of ofloxacin or 10 mg/kg of ciprofloxacin) with or without 13.3 mg/kg of sucralfate under fasted or fed condition and plasma concentration profiles of new quinolones were monitored. To the fed group, standard breakfast used in human studies was pasted and administered at a dose of 8.8 g/kg. RESULTS: The area under the plasma concentration - time curves (AUC(0–6)) of ofloxacin and ciprofloxacin under the fasted condition were significantly decreased to 28.8 and 17.1% by co-administration of sucralfate, respectively. On the contrary, sucralfate moderately decreased the AUC(0–6) of ofloxacin and ciprofloxacin to 54.9 and 33.2%, respectively, under fed condition. The effects of sucralfate and food intake on the kinetics of ofloxacin in this study were well consistent with the results of previous clinical trial. CONCLUSIONS: The developed animal model quantitatively reproduced the effect of food intake on the drug - drug interaction between ofloxacin and sucralfate. The similar influences were observed for the drug - drug interaction between ciprofloxacin and sucralfate, suggesting that the extent of drug - drug interaction caused by chelation is generally attenuated by food intake.
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spelling pubmed-59501392018-05-21 Food intake attenuates the drug interaction between new quinolones and aluminum Imaoka, Ayuko Abiru, Kosuke Akiyoshi, Takeshi Ohtani, Hisakazu J Pharm Health Care Sci Research Article BACKGROUND: Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food intake on the extent of drug - drug interaction between new quinolones and metal cations remains to be investigated quantitatively and systematically. The aim of this study was to develop an animal model that enables to evaluate the effect of food intake on the extent of drug - drug interaction in the gastrointestinal tract by chelation and to apply the model to evaluate quantitatively the effect of food intake on the drug - drug interaction between two new quinolones, ofloxacin or ciprofloxacin and sucralfate. METHODS: The rats were orally administered new quinolones (5.3 mg/kg of ofloxacin or 10 mg/kg of ciprofloxacin) with or without 13.3 mg/kg of sucralfate under fasted or fed condition and plasma concentration profiles of new quinolones were monitored. To the fed group, standard breakfast used in human studies was pasted and administered at a dose of 8.8 g/kg. RESULTS: The area under the plasma concentration - time curves (AUC(0–6)) of ofloxacin and ciprofloxacin under the fasted condition were significantly decreased to 28.8 and 17.1% by co-administration of sucralfate, respectively. On the contrary, sucralfate moderately decreased the AUC(0–6) of ofloxacin and ciprofloxacin to 54.9 and 33.2%, respectively, under fed condition. The effects of sucralfate and food intake on the kinetics of ofloxacin in this study were well consistent with the results of previous clinical trial. CONCLUSIONS: The developed animal model quantitatively reproduced the effect of food intake on the drug - drug interaction between ofloxacin and sucralfate. The similar influences were observed for the drug - drug interaction between ciprofloxacin and sucralfate, suggesting that the extent of drug - drug interaction caused by chelation is generally attenuated by food intake. BioMed Central 2018-05-14 /pmc/articles/PMC5950139/ /pubmed/29785276 http://dx.doi.org/10.1186/s40780-018-0107-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Imaoka, Ayuko
Abiru, Kosuke
Akiyoshi, Takeshi
Ohtani, Hisakazu
Food intake attenuates the drug interaction between new quinolones and aluminum
title Food intake attenuates the drug interaction between new quinolones and aluminum
title_full Food intake attenuates the drug interaction between new quinolones and aluminum
title_fullStr Food intake attenuates the drug interaction between new quinolones and aluminum
title_full_unstemmed Food intake attenuates the drug interaction between new quinolones and aluminum
title_short Food intake attenuates the drug interaction between new quinolones and aluminum
title_sort food intake attenuates the drug interaction between new quinolones and aluminum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950139/
https://www.ncbi.nlm.nih.gov/pubmed/29785276
http://dx.doi.org/10.1186/s40780-018-0107-1
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