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An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report

Objective: Infantile digital fibromatosis is a rare benign childhood tumor, infrequently cited in the literature. Hallmarks include nodular growths exclusive to fingers and toes and the presence of eosinophilic cytoplasmic inclusions on histology. This article aims to exemplify diagnoses of infantil...

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Autores principales: Eypper, Elizabeth H., Lee, Johnson C., Tarasen, Ashley J., Weinberg, Maxene H., Adetayo, Oluwaseun A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Science Company, LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950536/
https://www.ncbi.nlm.nih.gov/pubmed/29780440
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author Eypper, Elizabeth H.
Lee, Johnson C.
Tarasen, Ashley J.
Weinberg, Maxene H.
Adetayo, Oluwaseun A.
author_facet Eypper, Elizabeth H.
Lee, Johnson C.
Tarasen, Ashley J.
Weinberg, Maxene H.
Adetayo, Oluwaseun A.
author_sort Eypper, Elizabeth H.
collection PubMed
description Objective: Infantile digital fibromatosis is a rare benign childhood tumor, infrequently cited in the literature. Hallmarks include nodular growths exclusive to fingers and toes and the presence of eosinophilic cytoplasmic inclusions on histology. This article aims to exemplify diagnoses of infantile digital fibromatosis and possible treatment options. Methods: A computerized English literature search was performed in the PubMed/MEDLINE database using MeSH headings “infantile,” “juvenile,” “digital,” and “fibromatosis.” Twenty electronic publications were selected and their clinical and histological data recorded and used to compile a treatment algorithm. Results: A 9-month-old male child was referred for a persistent, symptomatic nodule on the third left toe. A direct excision with Brunner-type incisions was performed under general anesthesia. The procedure was successful without complications. The patient has no recurrence at 2 years postsurgery and continues to be followed. Histological examination revealed a proliferation of bland, uniformly plump spindle cells with elongated nuclei and small central nucleoli without paranuclear inclusions consistent with fibromatosis. Conclusions: Asymptomatic nodules should be observed for spontaneous regression or treated with nonsurgical techniques such as chemotherapeutic or steroid injection. Surgical removal should be reserved for cases with structural or functional compromise.
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spelling pubmed-59505362018-05-18 An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report Eypper, Elizabeth H. Lee, Johnson C. Tarasen, Ashley J. Weinberg, Maxene H. Adetayo, Oluwaseun A. Eplasty Journal Article Objective: Infantile digital fibromatosis is a rare benign childhood tumor, infrequently cited in the literature. Hallmarks include nodular growths exclusive to fingers and toes and the presence of eosinophilic cytoplasmic inclusions on histology. This article aims to exemplify diagnoses of infantile digital fibromatosis and possible treatment options. Methods: A computerized English literature search was performed in the PubMed/MEDLINE database using MeSH headings “infantile,” “juvenile,” “digital,” and “fibromatosis.” Twenty electronic publications were selected and their clinical and histological data recorded and used to compile a treatment algorithm. Results: A 9-month-old male child was referred for a persistent, symptomatic nodule on the third left toe. A direct excision with Brunner-type incisions was performed under general anesthesia. The procedure was successful without complications. The patient has no recurrence at 2 years postsurgery and continues to be followed. Histological examination revealed a proliferation of bland, uniformly plump spindle cells with elongated nuclei and small central nucleoli without paranuclear inclusions consistent with fibromatosis. Conclusions: Asymptomatic nodules should be observed for spontaneous regression or treated with nonsurgical techniques such as chemotherapeutic or steroid injection. Surgical removal should be reserved for cases with structural or functional compromise. Open Science Company, LLC 2018-05-07 /pmc/articles/PMC5950536/ /pubmed/29780440 Text en Copyright © 2018 The Author(s) http://creativecommons.org/licenses/by/2.0/ This is an open-access article whereby the authors retain copyright of the work. The article is distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Journal Article
Eypper, Elizabeth H.
Lee, Johnson C.
Tarasen, Ashley J.
Weinberg, Maxene H.
Adetayo, Oluwaseun A.
An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report
title An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report
title_full An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report
title_fullStr An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report
title_full_unstemmed An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report
title_short An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report
title_sort algorithmic approach to the management of infantile digital fibromatosis: review of literature and a case report
topic Journal Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950536/
https://www.ncbi.nlm.nih.gov/pubmed/29780440
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