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Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions

The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commens...

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Detalles Bibliográficos
Autores principales: Zhang, Sheng, Cai, Sanjun, Ma, Yanlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950595/
https://www.ncbi.nlm.nih.gov/pubmed/29760804
http://dx.doi.org/10.7150/jca.24048
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author Zhang, Sheng
Cai, Sanjun
Ma, Yanlei
author_facet Zhang, Sheng
Cai, Sanjun
Ma, Yanlei
author_sort Zhang, Sheng
collection PubMed
description The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commensal anaerobe in the oral cavity, has been associated with CRC. Several research teams have reported an overabundance of Fn in human CRC and have elucidated the possible mechanisms by which Fn is involved in colorectal carcinogenesis in vitro and in mouse models. However, the mechanisms by which Fn promotes colorectal carcinogenesis remain unclear. To provide new perspectives for early diagnosis, the identification of high risk populations and treatment for colorectal cancer, this review will summarize the relative research progresses regarding the relationship between Fn and colorectal cancer.
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spelling pubmed-59505952018-05-14 Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions Zhang, Sheng Cai, Sanjun Ma, Yanlei J Cancer Review The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commensal anaerobe in the oral cavity, has been associated with CRC. Several research teams have reported an overabundance of Fn in human CRC and have elucidated the possible mechanisms by which Fn is involved in colorectal carcinogenesis in vitro and in mouse models. However, the mechanisms by which Fn promotes colorectal carcinogenesis remain unclear. To provide new perspectives for early diagnosis, the identification of high risk populations and treatment for colorectal cancer, this review will summarize the relative research progresses regarding the relationship between Fn and colorectal cancer. Ivyspring International Publisher 2018-04-18 /pmc/articles/PMC5950595/ /pubmed/29760804 http://dx.doi.org/10.7150/jca.24048 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zhang, Sheng
Cai, Sanjun
Ma, Yanlei
Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
title Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
title_full Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
title_fullStr Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
title_full_unstemmed Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
title_short Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
title_sort association between fusobacterium nucleatum and colorectal cancer: progress and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950595/
https://www.ncbi.nlm.nih.gov/pubmed/29760804
http://dx.doi.org/10.7150/jca.24048
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