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The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I biotransformation. The most important role in biotransformation belongs to CYP3A4, CYP2D6, CYP2C9, CYP2C19 and CYP1A2. Inhibition and induction of CYP isoenzymes caused by drugs are important and clinically relevant pharmacoki...

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Detalles Bibliográficos
Autores principales:	Sychev, Dmitrij A, Ashraf, Ghulam Md, Svistunov, Andrey A, Maksimov, Maksim L, Tarasov, Vadim V, Chubarev, Vladimir N, Otdelenov, Vitalij A, Denisenko, Natal’ja P, Barreto, George E, Aliev, Gjumrakch
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951216/ https://www.ncbi.nlm.nih.gov/pubmed/29780235 http://dx.doi.org/10.2147/DDDT.S149069

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