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Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution

Silica nanoparticles are widely studied in emerging areas of nanomedicine because they are biocompatible, and their surface can be modified to provide functionalization. The size is intrinsically related to the performance of the silica nanoparticles; therefore, it is important to have control over...

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Autores principales: Chapa-González, Christian, Piñón-Urbina, Ana Laura, García-Casillas, Perla Elvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951356/
https://www.ncbi.nlm.nih.gov/pubmed/29597254
http://dx.doi.org/10.3390/ma11040510
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author Chapa-González, Christian
Piñón-Urbina, Ana Laura
García-Casillas, Perla Elvia
author_facet Chapa-González, Christian
Piñón-Urbina, Ana Laura
García-Casillas, Perla Elvia
author_sort Chapa-González, Christian
collection PubMed
description Silica nanoparticles are widely studied in emerging areas of nanomedicine because they are biocompatible, and their surface can be modified to provide functionalization. The size is intrinsically related to the performance of the silica nanoparticles; therefore, it is important to have control over the size. However, the silica nanoparticles obtained from sodium metasilicate are less studied than those obtained from tetraethyl orthosilicate. Moreover, the methods of surface modification involve several steps after the synthesis. In this work, the effect of different concentrations of sodium metasilicate on the size of silica nanoparticles was studied. In the same way, we studied the synthesis of organically modified silica nanoparticles in a one-step method, using poly(ethylene glycol). The nanoparticles were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. It was found that the size distribution of the silica nanoparticles could be modified by changing the initial concentration of sodium metasilicate. The one-step surface-modification method caused a significant decrease in size distribution.
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spelling pubmed-59513562018-05-15 Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution Chapa-González, Christian Piñón-Urbina, Ana Laura García-Casillas, Perla Elvia Materials (Basel) Article Silica nanoparticles are widely studied in emerging areas of nanomedicine because they are biocompatible, and their surface can be modified to provide functionalization. The size is intrinsically related to the performance of the silica nanoparticles; therefore, it is important to have control over the size. However, the silica nanoparticles obtained from sodium metasilicate are less studied than those obtained from tetraethyl orthosilicate. Moreover, the methods of surface modification involve several steps after the synthesis. In this work, the effect of different concentrations of sodium metasilicate on the size of silica nanoparticles was studied. In the same way, we studied the synthesis of organically modified silica nanoparticles in a one-step method, using poly(ethylene glycol). The nanoparticles were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. It was found that the size distribution of the silica nanoparticles could be modified by changing the initial concentration of sodium metasilicate. The one-step surface-modification method caused a significant decrease in size distribution. MDPI 2018-03-28 /pmc/articles/PMC5951356/ /pubmed/29597254 http://dx.doi.org/10.3390/ma11040510 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chapa-González, Christian
Piñón-Urbina, Ana Laura
García-Casillas, Perla Elvia
Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution
title Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution
title_full Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution
title_fullStr Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution
title_full_unstemmed Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution
title_short Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution
title_sort synthesis of controlled-size silica nanoparticles from sodium metasilicate and the effect of the addition of peg in the size distribution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951356/
https://www.ncbi.nlm.nih.gov/pubmed/29597254
http://dx.doi.org/10.3390/ma11040510
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