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Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is app...

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Detalles Bibliográficos
Autores principales: Romano, Silvia, Lamberti, Annalisa, Masullo, Mariorosario, Penzo, Erika, Cabrini, Stefano, Rendina, Ivo, Mocella, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951372/
https://www.ncbi.nlm.nih.gov/pubmed/29601484
http://dx.doi.org/10.3390/ma11040526
Descripción
Sumario:A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range.