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Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly

Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation. FXN deficiency is associated with Friedreich ataxia, a neurodegenerative disease. We have used a combination of isothermal titration calorimetry and multinuclear NMR spe...

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Detalles Bibliográficos
Autores principales:	Cai, Kai, Frederick, Ronnie O., Tonelli, Marco, Markley, John L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951399/ https://www.ncbi.nlm.nih.gov/pubmed/29576242 http://dx.doi.org/10.1016/j.jinorgbio.2018.03.007

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