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Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals

Silver nanoparticles have been widely used in the lighting and food industries, in medicine, and in pharmaceutics as an antiseptic agent. Recent research demonstrates that, after prolonged oral administration, silver nanoparticles may cross the blood-brain barrier and accumulate in the brain in rath...

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Autores principales: Antsiferova, Anna, Kopaeva, Marina, Kashkarov, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951442/
https://www.ncbi.nlm.nih.gov/pubmed/29621146
http://dx.doi.org/10.3390/ma11040558
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author Antsiferova, Anna
Kopaeva, Marina
Kashkarov, Pavel
author_facet Antsiferova, Anna
Kopaeva, Marina
Kashkarov, Pavel
author_sort Antsiferova, Anna
collection PubMed
description Silver nanoparticles have been widely used in the lighting and food industries, in medicine, and in pharmaceutics as an antiseptic agent. Recent research demonstrates that, after prolonged oral administration, silver nanoparticles may cross the blood-brain barrier and accumulate in the brain in rather high amounts. In ex vivo experiments, it has also been shown that silver nanoparticles demonstrate neurotoxicity. The objective of this work was to answer the questions whether silver nanoparticles change cognitive and behavioral functions of mammals after prolonged administration if silver nanoparticles have accumulated in the brain. C57Bl/6 male mice were orally exposed to PVP-coated silver nanoparticles daily for 30, 60, 120 and 180 days. Control mice were exposed to distilled water. After that they were tested in the Open Field, Elevated Plus Maze, Light-Dark Box and contextual fear conditioning task. The data have shown that the experimental mice went through three periods of switching in the behavior caused by adaptation to the toxic silver nanoparticles: anxiety, appearance of research instinct and impairment of long-term memory. This provides evidence of the hazardous effect of silver nanoparticles, which appears after long periods of silver nanoparticle oral administration.
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spelling pubmed-59514422018-05-15 Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals Antsiferova, Anna Kopaeva, Marina Kashkarov, Pavel Materials (Basel) Article Silver nanoparticles have been widely used in the lighting and food industries, in medicine, and in pharmaceutics as an antiseptic agent. Recent research demonstrates that, after prolonged oral administration, silver nanoparticles may cross the blood-brain barrier and accumulate in the brain in rather high amounts. In ex vivo experiments, it has also been shown that silver nanoparticles demonstrate neurotoxicity. The objective of this work was to answer the questions whether silver nanoparticles change cognitive and behavioral functions of mammals after prolonged administration if silver nanoparticles have accumulated in the brain. C57Bl/6 male mice were orally exposed to PVP-coated silver nanoparticles daily for 30, 60, 120 and 180 days. Control mice were exposed to distilled water. After that they were tested in the Open Field, Elevated Plus Maze, Light-Dark Box and contextual fear conditioning task. The data have shown that the experimental mice went through three periods of switching in the behavior caused by adaptation to the toxic silver nanoparticles: anxiety, appearance of research instinct and impairment of long-term memory. This provides evidence of the hazardous effect of silver nanoparticles, which appears after long periods of silver nanoparticle oral administration. MDPI 2018-04-05 /pmc/articles/PMC5951442/ /pubmed/29621146 http://dx.doi.org/10.3390/ma11040558 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Antsiferova, Anna
Kopaeva, Marina
Kashkarov, Pavel
Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
title Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
title_full Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
title_fullStr Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
title_full_unstemmed Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
title_short Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
title_sort effects of prolonged silver nanoparticle exposure on the contextual cognition and behavior of mammals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951442/
https://www.ncbi.nlm.nih.gov/pubmed/29621146
http://dx.doi.org/10.3390/ma11040558
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