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The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides
Immunogenicity is a major concern in drug development as anti-drug antibodies in many cases affect both patient safety and drug efficacy. Another concern is often the limited half-life of drugs, which can be altered by different chemical modifications, like acylation with fatty acids. However, acyla...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951580/ https://www.ncbi.nlm.nih.gov/pubmed/29758051 http://dx.doi.org/10.1371/journal.pone.0197407 |