Cargando…
The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides
Immunogenicity is a major concern in drug development as anti-drug antibodies in many cases affect both patient safety and drug efficacy. Another concern is often the limited half-life of drugs, which can be altered by different chemical modifications, like acylation with fatty acids. However, acyla...
Autores principales: | Schultz, Heidi S., Østergaard, Søren, Sidney, John, Lamberth, Kasper, Sette, Alessandro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951580/ https://www.ncbi.nlm.nih.gov/pubmed/29758051 http://dx.doi.org/10.1371/journal.pone.0197407 |
Ejemplares similares
-
NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence
por: Nielsen, Morten, et al.
Publicado: (2007) -
Functional recombinant MHC class II molecules and high-throughput peptide-binding assays
por: Justesen, Sune, et al.
Publicado: (2009) -
Citrullination only infrequently impacts peptide binding to HLA class II MHC
por: Sidney, John, et al.
Publicado: (2017) -
Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities
por: Pedersen, Lasse Eggers, et al.
Publicado: (2011) -
NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8–11
por: Lundegaard, Claus, et al.
Publicado: (2008)