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The extent of liver injury determines hepatocyte fate toward senescence or cancer

It is well known that induction of hepatocyte senescence could inhibit the development of hepatocellular carcinoma (HCC). Until now, it is still unclear how the degree of liver injury dictates hepatocyte senescence and carcinogenesis. In this study, we investigated whether the severity of injury det...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Chen, Wen-Jian, Wu, Ying-Fu, You, Pu, Zheng, Shang-Yong, Liu, Chang-Cheng, Xiang, Dao, Wang, Min-Jun, Cai, Yong-Chao, Zhao, Qing-Hui, Borjigin, Uyunbilig, Liu, Wei, Xiong, Wu-Jun, Wangensteen, Kirk J., Wang, Xin, Liu, Zhong-Min, He, Zhi-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951829/
https://www.ncbi.nlm.nih.gov/pubmed/29760381
http://dx.doi.org/10.1038/s41419-018-0622-x