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Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex
Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been the most studied, whereas little is known about direct corticospinal modula...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951839/ https://www.ncbi.nlm.nih.gov/pubmed/29760484 http://dx.doi.org/10.1038/s41467-018-04309-2 |
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author | Chen, Tao Taniguchi, Wataru Chen, Qi-Yu Tozaki-Saitoh, Hidetoshi Song, Qian Liu, Ren-Hao Koga, Kohei Matsuda, Tsuyoshi Kaito-Sugimura, Yae Wang, Jian Li, Zhi-Hua Lu, Ya-Cheng Inoue, Kazuhide Tsuda, Makoto Li, Yun-Qing Nakatsuka, Terumasa Zhuo, Min |
author_facet | Chen, Tao Taniguchi, Wataru Chen, Qi-Yu Tozaki-Saitoh, Hidetoshi Song, Qian Liu, Ren-Hao Koga, Kohei Matsuda, Tsuyoshi Kaito-Sugimura, Yae Wang, Jian Li, Zhi-Hua Lu, Ya-Cheng Inoue, Kazuhide Tsuda, Makoto Li, Yun-Qing Nakatsuka, Terumasa Zhuo, Min |
author_sort | Chen, Tao |
collection | PubMed |
description | Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been the most studied, whereas little is known about direct corticospinal modulation. Here, we found that stimulation in the anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic transmission and this modulation is independent of the RVM. Peripheral nerve injury enhanced the spinal synaptic transmission and occluded the ACC-spinal cord facilitation. Inhibition of ACC reduced the enhanced spinal synaptic transmission caused by nerve injury. Finally, using optogenetics, we showed that selective activation of ACC-spinal cord projecting neurons caused behavioral pain sensitization, while inhibiting the projection induced analgesic effects. Our results provide strong evidence that ACC stimulation facilitates spinal sensory excitatory transmission by a RVM-independent manner, and that such top-down facilitation may contribute to the process of chronic neuropathic pain. |
format | Online Article Text |
id | pubmed-5951839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59518392018-05-16 Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex Chen, Tao Taniguchi, Wataru Chen, Qi-Yu Tozaki-Saitoh, Hidetoshi Song, Qian Liu, Ren-Hao Koga, Kohei Matsuda, Tsuyoshi Kaito-Sugimura, Yae Wang, Jian Li, Zhi-Hua Lu, Ya-Cheng Inoue, Kazuhide Tsuda, Makoto Li, Yun-Qing Nakatsuka, Terumasa Zhuo, Min Nat Commun Article Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been the most studied, whereas little is known about direct corticospinal modulation. Here, we found that stimulation in the anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic transmission and this modulation is independent of the RVM. Peripheral nerve injury enhanced the spinal synaptic transmission and occluded the ACC-spinal cord facilitation. Inhibition of ACC reduced the enhanced spinal synaptic transmission caused by nerve injury. Finally, using optogenetics, we showed that selective activation of ACC-spinal cord projecting neurons caused behavioral pain sensitization, while inhibiting the projection induced analgesic effects. Our results provide strong evidence that ACC stimulation facilitates spinal sensory excitatory transmission by a RVM-independent manner, and that such top-down facilitation may contribute to the process of chronic neuropathic pain. Nature Publishing Group UK 2018-05-14 /pmc/articles/PMC5951839/ /pubmed/29760484 http://dx.doi.org/10.1038/s41467-018-04309-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chen, Tao Taniguchi, Wataru Chen, Qi-Yu Tozaki-Saitoh, Hidetoshi Song, Qian Liu, Ren-Hao Koga, Kohei Matsuda, Tsuyoshi Kaito-Sugimura, Yae Wang, Jian Li, Zhi-Hua Lu, Ya-Cheng Inoue, Kazuhide Tsuda, Makoto Li, Yun-Qing Nakatsuka, Terumasa Zhuo, Min Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
title | Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
title_full | Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
title_fullStr | Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
title_full_unstemmed | Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
title_short | Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
title_sort | top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951839/ https://www.ncbi.nlm.nih.gov/pubmed/29760484 http://dx.doi.org/10.1038/s41467-018-04309-2 |
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