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A paradox of epidemics between the state and parameter spaces

It is recently revealed from amounts of real data of recurrent epidemics that there is a phenomenon of hysteresis loop in the state space. To understand it, an indirect investigation from the parameter space has been given to qualitatively explain its mechanism but a more convincing study to quantit...

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Autores principales: Liu, Hengcong, Zheng, Muhua, Liu, Zonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951842/
https://www.ncbi.nlm.nih.gov/pubmed/29760412
http://dx.doi.org/10.1038/s41598-018-25931-6
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author Liu, Hengcong
Zheng, Muhua
Liu, Zonghua
author_facet Liu, Hengcong
Zheng, Muhua
Liu, Zonghua
author_sort Liu, Hengcong
collection PubMed
description It is recently revealed from amounts of real data of recurrent epidemics that there is a phenomenon of hysteresis loop in the state space. To understand it, an indirect investigation from the parameter space has been given to qualitatively explain its mechanism but a more convincing study to quantitatively explain the phenomenon directly from the state space is still missing. We here study this phenomenon directly from the state space and find that there is a positive correlation between the size of outbreak and the size of hysteresis loop, implying that the hysteresis is a nature feature of epidemic outbreak in real case. Moreover, we surprisingly find a paradox on the dependence of the size of hysteresis loop on the two parameters of the infectious rate increment and the transient time, i.e. contradictory behaviors between the two spaces, when the evolutionary time of epidemics is long enough. That is, with the increase of the infectious rate increment, the size of hysteresis loop will decrease in the state space but increase in the parameter space. While with the increase of the transient time, the size of hysteresis loop will increase in the state space but decrease in the parameter space. Furthermore, we find that this paradox will disappear when the evolutionary time of epidemics is limited in a fixed period. Some theoretical analysis are presented to both the paradox and other numerical results.
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spelling pubmed-59518422018-05-21 A paradox of epidemics between the state and parameter spaces Liu, Hengcong Zheng, Muhua Liu, Zonghua Sci Rep Article It is recently revealed from amounts of real data of recurrent epidemics that there is a phenomenon of hysteresis loop in the state space. To understand it, an indirect investigation from the parameter space has been given to qualitatively explain its mechanism but a more convincing study to quantitatively explain the phenomenon directly from the state space is still missing. We here study this phenomenon directly from the state space and find that there is a positive correlation between the size of outbreak and the size of hysteresis loop, implying that the hysteresis is a nature feature of epidemic outbreak in real case. Moreover, we surprisingly find a paradox on the dependence of the size of hysteresis loop on the two parameters of the infectious rate increment and the transient time, i.e. contradictory behaviors between the two spaces, when the evolutionary time of epidemics is long enough. That is, with the increase of the infectious rate increment, the size of hysteresis loop will decrease in the state space but increase in the parameter space. While with the increase of the transient time, the size of hysteresis loop will increase in the state space but decrease in the parameter space. Furthermore, we find that this paradox will disappear when the evolutionary time of epidemics is limited in a fixed period. Some theoretical analysis are presented to both the paradox and other numerical results. Nature Publishing Group UK 2018-05-14 /pmc/articles/PMC5951842/ /pubmed/29760412 http://dx.doi.org/10.1038/s41598-018-25931-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Hengcong
Zheng, Muhua
Liu, Zonghua
A paradox of epidemics between the state and parameter spaces
title A paradox of epidemics between the state and parameter spaces
title_full A paradox of epidemics between the state and parameter spaces
title_fullStr A paradox of epidemics between the state and parameter spaces
title_full_unstemmed A paradox of epidemics between the state and parameter spaces
title_short A paradox of epidemics between the state and parameter spaces
title_sort paradox of epidemics between the state and parameter spaces
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951842/
https://www.ncbi.nlm.nih.gov/pubmed/29760412
http://dx.doi.org/10.1038/s41598-018-25931-6
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