Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimic...

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Detalles Bibliográficos
Autores principales: Clark, Lars E., Mahmutovic, Selma, Raymond, Donald D., Dilanyan, Taleen, Koma, Takaaki, Manning, John T., Shankar, Sundaresh, Levis, Silvana C., Briggiler, Ana M., Enria, Delia A., Wucherpfennig, Kai W., Paessler, Slobodan, Abraham, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951886/
https://www.ncbi.nlm.nih.gov/pubmed/29760382
http://dx.doi.org/10.1038/s41467-018-04271-z

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