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Neural encoding and production of functional morphemes in the posterior temporal lobe

Morphemes are the smallest meaning-carrying units in human language, and are among the most basic building blocks through which humans express specific ideas and concepts. By using time-resolved cortical stimulations, neural recordings, and focal lesion evaluations, we show that inhibition of a smal...

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Autores principales: Lee, Daniel K., Fedorenko, Evelina, Simon, Mirela V., Curry, William T., Nahed, Brian V., Cahill, Dan P., Williams, Ziv M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951905/
https://www.ncbi.nlm.nih.gov/pubmed/29760465
http://dx.doi.org/10.1038/s41467-018-04235-3
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author Lee, Daniel K.
Fedorenko, Evelina
Simon, Mirela V.
Curry, William T.
Nahed, Brian V.
Cahill, Dan P.
Williams, Ziv M.
author_facet Lee, Daniel K.
Fedorenko, Evelina
Simon, Mirela V.
Curry, William T.
Nahed, Brian V.
Cahill, Dan P.
Williams, Ziv M.
author_sort Lee, Daniel K.
collection PubMed
description Morphemes are the smallest meaning-carrying units in human language, and are among the most basic building blocks through which humans express specific ideas and concepts. By using time-resolved cortical stimulations, neural recordings, and focal lesion evaluations, we show that inhibition of a small cortical area within the left dominant posterior–superior temporal lobe selectively impairs the ability to produce appropriate functional morphemes but does not distinctly affect semantic and lexical retrieval, comprehension, or articulation. Additionally, neural recordings within this area reveal the localized encoding of morphological properties and their planned production prior to speech onset. Finally, small lesions localized to the gray matter in this area result in a selective functional morpheme-production deficit. Collectively, these findings reveal a detailed division of linguistic labor within the posterior–superior temporal lobe and suggest that functional morpheme processing constitutes an operationally discrete step in the series of computations essential to language production.
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spelling pubmed-59519052018-05-16 Neural encoding and production of functional morphemes in the posterior temporal lobe Lee, Daniel K. Fedorenko, Evelina Simon, Mirela V. Curry, William T. Nahed, Brian V. Cahill, Dan P. Williams, Ziv M. Nat Commun Article Morphemes are the smallest meaning-carrying units in human language, and are among the most basic building blocks through which humans express specific ideas and concepts. By using time-resolved cortical stimulations, neural recordings, and focal lesion evaluations, we show that inhibition of a small cortical area within the left dominant posterior–superior temporal lobe selectively impairs the ability to produce appropriate functional morphemes but does not distinctly affect semantic and lexical retrieval, comprehension, or articulation. Additionally, neural recordings within this area reveal the localized encoding of morphological properties and their planned production prior to speech onset. Finally, small lesions localized to the gray matter in this area result in a selective functional morpheme-production deficit. Collectively, these findings reveal a detailed division of linguistic labor within the posterior–superior temporal lobe and suggest that functional morpheme processing constitutes an operationally discrete step in the series of computations essential to language production. Nature Publishing Group UK 2018-05-14 /pmc/articles/PMC5951905/ /pubmed/29760465 http://dx.doi.org/10.1038/s41467-018-04235-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lee, Daniel K.
Fedorenko, Evelina
Simon, Mirela V.
Curry, William T.
Nahed, Brian V.
Cahill, Dan P.
Williams, Ziv M.
Neural encoding and production of functional morphemes in the posterior temporal lobe
title Neural encoding and production of functional morphemes in the posterior temporal lobe
title_full Neural encoding and production of functional morphemes in the posterior temporal lobe
title_fullStr Neural encoding and production of functional morphemes in the posterior temporal lobe
title_full_unstemmed Neural encoding and production of functional morphemes in the posterior temporal lobe
title_short Neural encoding and production of functional morphemes in the posterior temporal lobe
title_sort neural encoding and production of functional morphemes in the posterior temporal lobe
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951905/
https://www.ncbi.nlm.nih.gov/pubmed/29760465
http://dx.doi.org/10.1038/s41467-018-04235-3
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