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GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging

Defects in the nuclear lamina occur during physiological aging and as a result of premature aging disorders. Aging is also accompanied by an increase in transcription of genes encoding cytokines and chemokines, a phenomenon known as the senescence-associated secretory phenotype (SASP). Progerin and...

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Detalles Bibliográficos
Autores principales:	Lee, Jin Young, Yu, Kyung-Rok, Lee, Byung-Chul, Kang, Insung, Kim, Jae-Jun, Jung, Eui-Jung, Kim, Hyung-Sik, Seo, Yoojin, Choi, Soon Won, Kang, Kyung-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951912/ https://www.ncbi.nlm.nih.gov/pubmed/29760459 http://dx.doi.org/10.1038/s12276-018-0092-3

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