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Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis
The retrosplenial cortex has long been implicated in human spatial orientation and navigation. However, neural activity peaks labeled “retrosplenial cortex” in human neuroimaging studies investigating spatial orientation often lie significantly outside of the retrosplenial cortex proper. This has le...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951926/ https://www.ncbi.nlm.nih.gov/pubmed/29867414 http://dx.doi.org/10.3389/fnhum.2018.00190 |
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author | Burles, Ford Umiltá, Alberto McFarlane, Liam H. Potocki, Kendra Iaria, Giuseppe |
author_facet | Burles, Ford Umiltá, Alberto McFarlane, Liam H. Potocki, Kendra Iaria, Giuseppe |
author_sort | Burles, Ford |
collection | PubMed |
description | The retrosplenial cortex has long been implicated in human spatial orientation and navigation. However, neural activity peaks labeled “retrosplenial cortex” in human neuroimaging studies investigating spatial orientation often lie significantly outside of the retrosplenial cortex proper. This has led to a large and anatomically heterogenous region being ascribed numerous roles in spatial orientation and navigation. Here, we performed a meta-analysis of functional Magnetic Resonance Imaging (fMRI) investigations of spatial orientation and navigation and have identified a ventral-dorsal functional specialization within the posterior cingulate for spatial encoding vs. spatial recall. Generally, ventral portions of the posterior cingulate cortex were more likely to be activated by spatial encoding, i.e., passive viewing of scenes or active navigation without a demand to respond, perform a spatial computation, or localize oneself in the environment. Conversely, dorsal portions of the posterior cingulate cortex were more likely to be activated by cognitive demands to recall spatial information or to produce judgments of distance or direction to non-visible locations or landmarks. The greatly varying resting-state functional connectivity profiles of the ventral (centroids at MNI −22, −60, 6 and 20, −56, 6) and dorsal (centroid at MNI 4, −60, 28) posterior cingulate regions identified in the meta-analysis supported the conclusion that these regions, which would commonly be labeled as “retrosplenial cortex,” should be more appropriately referred to as distinct subregions of the posterior cingulate cortex. We suggest that future studies investigating the role of the retrosplenial and posterior cingulate cortex in spatial tasks carefully localize activity in the context of these identifiable subregions. |
format | Online Article Text |
id | pubmed-5951926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59519262018-06-04 Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis Burles, Ford Umiltá, Alberto McFarlane, Liam H. Potocki, Kendra Iaria, Giuseppe Front Hum Neurosci Neuroscience The retrosplenial cortex has long been implicated in human spatial orientation and navigation. However, neural activity peaks labeled “retrosplenial cortex” in human neuroimaging studies investigating spatial orientation often lie significantly outside of the retrosplenial cortex proper. This has led to a large and anatomically heterogenous region being ascribed numerous roles in spatial orientation and navigation. Here, we performed a meta-analysis of functional Magnetic Resonance Imaging (fMRI) investigations of spatial orientation and navigation and have identified a ventral-dorsal functional specialization within the posterior cingulate for spatial encoding vs. spatial recall. Generally, ventral portions of the posterior cingulate cortex were more likely to be activated by spatial encoding, i.e., passive viewing of scenes or active navigation without a demand to respond, perform a spatial computation, or localize oneself in the environment. Conversely, dorsal portions of the posterior cingulate cortex were more likely to be activated by cognitive demands to recall spatial information or to produce judgments of distance or direction to non-visible locations or landmarks. The greatly varying resting-state functional connectivity profiles of the ventral (centroids at MNI −22, −60, 6 and 20, −56, 6) and dorsal (centroid at MNI 4, −60, 28) posterior cingulate regions identified in the meta-analysis supported the conclusion that these regions, which would commonly be labeled as “retrosplenial cortex,” should be more appropriately referred to as distinct subregions of the posterior cingulate cortex. We suggest that future studies investigating the role of the retrosplenial and posterior cingulate cortex in spatial tasks carefully localize activity in the context of these identifiable subregions. Frontiers Media S.A. 2018-05-08 /pmc/articles/PMC5951926/ /pubmed/29867414 http://dx.doi.org/10.3389/fnhum.2018.00190 Text en Copyright © 2018 Burles, Umiltá, McFarlane, Potocki and Iaria. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Burles, Ford Umiltá, Alberto McFarlane, Liam H. Potocki, Kendra Iaria, Giuseppe Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis |
title | Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis |
title_full | Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis |
title_fullStr | Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis |
title_full_unstemmed | Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis |
title_short | Ventral—Dorsal Functional Contribution of the Posterior Cingulate Cortex in Human Spatial Orientation: A Meta-Analysis |
title_sort | ventral—dorsal functional contribution of the posterior cingulate cortex in human spatial orientation: a meta-analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951926/ https://www.ncbi.nlm.nih.gov/pubmed/29867414 http://dx.doi.org/10.3389/fnhum.2018.00190 |
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