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Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes

BACKGROUND: The ultrasonographic characteristics and difference for various subtypes of papillary thyroid carcinoma (PTC) are still unclear. The aim of this study was to compare the ultrasonographic features of PTC according to its subtype in patients undergoing thyroid surgery. METHODS: In total, 1...

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Autores principales: Baek, Hye Jin, Kim, Dong Wook, Shin, Gi Won, Heo, Young Jin, Baek, Jin Wook, Lee, Yoo Jin, Cho, Young Jun, Park, Ha Kyoung, Ha, Tae Kwun, Kim, Do Hun, Jung, Soo Jin, Park, Ji Sun, Ahn, Ki Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951938/
https://www.ncbi.nlm.nih.gov/pubmed/29867759
http://dx.doi.org/10.3389/fendo.2018.00223
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author Baek, Hye Jin
Kim, Dong Wook
Shin, Gi Won
Heo, Young Jin
Baek, Jin Wook
Lee, Yoo Jin
Cho, Young Jun
Park, Ha Kyoung
Ha, Tae Kwun
Kim, Do Hun
Jung, Soo Jin
Park, Ji Sun
Ahn, Ki Jung
author_facet Baek, Hye Jin
Kim, Dong Wook
Shin, Gi Won
Heo, Young Jin
Baek, Jin Wook
Lee, Yoo Jin
Cho, Young Jun
Park, Ha Kyoung
Ha, Tae Kwun
Kim, Do Hun
Jung, Soo Jin
Park, Ji Sun
Ahn, Ki Jung
author_sort Baek, Hye Jin
collection PubMed
description BACKGROUND: The ultrasonographic characteristics and difference for various subtypes of papillary thyroid carcinoma (PTC) are still unclear. The aim of this study was to compare the ultrasonographic features of PTC according to its subtype in patients undergoing thyroid surgery. METHODS: In total, 140 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery between January 2016 and December 2016 were included. The ultrasonographic features and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) category of each thyroid nodule were retrospectively evaluated by a single radiologist, and differences in ultrasonographic features according to the PTC subtype were assessed. RESULTS: According to histopathological analyses, there were 97 classic PTCs (62.2%), 34 follicular variants (21.8%), 5 tall cell variants (3.2%), 2 oncocytic variants (1.3%), 1 Warthin-like variant (0.6%), and 1 diffuse sclerosing variant (0.6%). Most PTCs were classified under K-TIRADS category 5. Among the ultrasonographic features, the nodule margin and the presence of calcification were significantly different among the PTC subtypes. A spiculated/microlobulated margin was the most common type of margin, regardless of the PTC subtype. In particular, all tall cell variants exhibited a spiculated/microlobulated margin. The classic PTC group exhibited the highest prevalence of intranodular calcification, with microcalcification being the most common. The prevalence of multiplicity and nodal metastasis was high in the tall cell variant group. CONCLUSION: The majority of PTCs in the present study belonged to K-TIRADS category 5, regardless of the subtype. Our findings suggest that ultrasonographic features are not useful for distinguishing PTC subtypes.
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spelling pubmed-59519382018-06-04 Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes Baek, Hye Jin Kim, Dong Wook Shin, Gi Won Heo, Young Jin Baek, Jin Wook Lee, Yoo Jin Cho, Young Jun Park, Ha Kyoung Ha, Tae Kwun Kim, Do Hun Jung, Soo Jin Park, Ji Sun Ahn, Ki Jung Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The ultrasonographic characteristics and difference for various subtypes of papillary thyroid carcinoma (PTC) are still unclear. The aim of this study was to compare the ultrasonographic features of PTC according to its subtype in patients undergoing thyroid surgery. METHODS: In total, 140 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery between January 2016 and December 2016 were included. The ultrasonographic features and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) category of each thyroid nodule were retrospectively evaluated by a single radiologist, and differences in ultrasonographic features according to the PTC subtype were assessed. RESULTS: According to histopathological analyses, there were 97 classic PTCs (62.2%), 34 follicular variants (21.8%), 5 tall cell variants (3.2%), 2 oncocytic variants (1.3%), 1 Warthin-like variant (0.6%), and 1 diffuse sclerosing variant (0.6%). Most PTCs were classified under K-TIRADS category 5. Among the ultrasonographic features, the nodule margin and the presence of calcification were significantly different among the PTC subtypes. A spiculated/microlobulated margin was the most common type of margin, regardless of the PTC subtype. In particular, all tall cell variants exhibited a spiculated/microlobulated margin. The classic PTC group exhibited the highest prevalence of intranodular calcification, with microcalcification being the most common. The prevalence of multiplicity and nodal metastasis was high in the tall cell variant group. CONCLUSION: The majority of PTCs in the present study belonged to K-TIRADS category 5, regardless of the subtype. Our findings suggest that ultrasonographic features are not useful for distinguishing PTC subtypes. Frontiers Media S.A. 2018-05-08 /pmc/articles/PMC5951938/ /pubmed/29867759 http://dx.doi.org/10.3389/fendo.2018.00223 Text en Copyright © 2018 Baek, Kim, Shin, Heo, Baek, Lee, Cho, Park, Ha, Kim, Jung, Park and Ahn. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Baek, Hye Jin
Kim, Dong Wook
Shin, Gi Won
Heo, Young Jin
Baek, Jin Wook
Lee, Yoo Jin
Cho, Young Jun
Park, Ha Kyoung
Ha, Tae Kwun
Kim, Do Hun
Jung, Soo Jin
Park, Ji Sun
Ahn, Ki Jung
Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes
title Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes
title_full Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes
title_fullStr Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes
title_full_unstemmed Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes
title_short Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes
title_sort ultrasonographic features of papillary thyroid carcinomas according to their subtypes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951938/
https://www.ncbi.nlm.nih.gov/pubmed/29867759
http://dx.doi.org/10.3389/fendo.2018.00223
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