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Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities
Donor organ shortage remains a clear problem for many end-stage organ patients around the world. The number of available donor organs pales in comparison with the number of patients in need of these organs. The field of tissue engineering proposes a plausible solution. Using stem cells, a patient’s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952288/ https://www.ncbi.nlm.nih.gov/pubmed/29780570 http://dx.doi.org/10.1177/2041731418772949 |
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author | Kottamasu, Pavan Herman, Ira |
author_facet | Kottamasu, Pavan Herman, Ira |
author_sort | Kottamasu, Pavan |
collection | PubMed |
description | Donor organ shortage remains a clear problem for many end-stage organ patients around the world. The number of available donor organs pales in comparison with the number of patients in need of these organs. The field of tissue engineering proposes a plausible solution. Using stem cells, a patient’s autologous cells, or allografted cells to seed-engineered scaffolds, tissue-engineered constructs can effectively supplement the donor pool and bypass other problems that arise when using donor organs, such as who receives the organ first and whether donor organ rejection may occur. However, current research methods and technologies have been unable to successfully engineer and vascularize large volume tissue constructs. This review examines the current perfusion methods for ex vivo organ systems, defines the different types of vascularization in organs, explores various strategies to vascularize ex vivo organ systems, and discusses challenges and opportunities for the field of tissue engineering. |
format | Online Article Text |
id | pubmed-5952288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-59522882018-05-18 Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities Kottamasu, Pavan Herman, Ira J Tissue Eng Review Donor organ shortage remains a clear problem for many end-stage organ patients around the world. The number of available donor organs pales in comparison with the number of patients in need of these organs. The field of tissue engineering proposes a plausible solution. Using stem cells, a patient’s autologous cells, or allografted cells to seed-engineered scaffolds, tissue-engineered constructs can effectively supplement the donor pool and bypass other problems that arise when using donor organs, such as who receives the organ first and whether donor organ rejection may occur. However, current research methods and technologies have been unable to successfully engineer and vascularize large volume tissue constructs. This review examines the current perfusion methods for ex vivo organ systems, defines the different types of vascularization in organs, explores various strategies to vascularize ex vivo organ systems, and discusses challenges and opportunities for the field of tissue engineering. SAGE Publications 2018-05-10 /pmc/articles/PMC5952288/ /pubmed/29780570 http://dx.doi.org/10.1177/2041731418772949 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Kottamasu, Pavan Herman, Ira Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities |
title | Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities |
title_full | Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities |
title_fullStr | Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities |
title_full_unstemmed | Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities |
title_short | Engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: Challenges and opportunities |
title_sort | engineering a microcirculation for perfusion control of ex vivo–assembled organ systems: challenges and opportunities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952288/ https://www.ncbi.nlm.nih.gov/pubmed/29780570 http://dx.doi.org/10.1177/2041731418772949 |
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