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Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency
A neural correlate for saccadic reaction times (SRTs) in the gap saccade task is the level of low-frequency activity in the intermediate layers of the superior colliculus (iSC) just before visual target onset: greater levels of such preparatory iSC low-frequency activity precede shorter SRTs. The fr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952303/ https://www.ncbi.nlm.nih.gov/pubmed/29766038 http://dx.doi.org/10.1523/ENEURO.0024-18.2018 |
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author | Dash, Suryadeep Peel, Tyler R. Lomber, Stephen G. Corneil, Brian D. |
author_facet | Dash, Suryadeep Peel, Tyler R. Lomber, Stephen G. Corneil, Brian D. |
author_sort | Dash, Suryadeep |
collection | PubMed |
description | A neural correlate for saccadic reaction times (SRTs) in the gap saccade task is the level of low-frequency activity in the intermediate layers of the superior colliculus (iSC) just before visual target onset: greater levels of such preparatory iSC low-frequency activity precede shorter SRTs. The frontal eye fields (FEFs) are one likely source of iSC preparatory activity, since FEF preparatory activity is also inversely related to SRT. To better understand the FEF’s role in saccade preparation, and the way in which such preparation relates to SRT, in two male rhesus monkeys, we compared iSC preparatory activity across unilateral reversible cryogenic inactivation of the FEF. FEF inactivation increased contralesional SRTs, and lowered ipsilesional iSC preparatory activity. FEF inactivation also reduced rostral iSC activity during the gap period. Importantly, the distributions of SRTs generated with or without FEF inactivation overlapped, enabling us to conduct a novel population-level analyses examining iSC preparatory activity just before generation of SRT-matched saccades. When matched for SRTs, we observed no change during FEF inactivation in the relationship between iSC preparatory activity and SRT-matched saccades across a range of SRTs, even for the occasional express saccade. Thus, while our results emphasize that the FEF has an overall excitatory influence on preparatory activity in the iSC, the communication between the iSC and downstream oculomotor brainstem is unaltered for SRT-matched saccades. |
format | Online Article Text |
id | pubmed-5952303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-59523032018-05-15 Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency Dash, Suryadeep Peel, Tyler R. Lomber, Stephen G. Corneil, Brian D. eNeuro New Research A neural correlate for saccadic reaction times (SRTs) in the gap saccade task is the level of low-frequency activity in the intermediate layers of the superior colliculus (iSC) just before visual target onset: greater levels of such preparatory iSC low-frequency activity precede shorter SRTs. The frontal eye fields (FEFs) are one likely source of iSC preparatory activity, since FEF preparatory activity is also inversely related to SRT. To better understand the FEF’s role in saccade preparation, and the way in which such preparation relates to SRT, in two male rhesus monkeys, we compared iSC preparatory activity across unilateral reversible cryogenic inactivation of the FEF. FEF inactivation increased contralesional SRTs, and lowered ipsilesional iSC preparatory activity. FEF inactivation also reduced rostral iSC activity during the gap period. Importantly, the distributions of SRTs generated with or without FEF inactivation overlapped, enabling us to conduct a novel population-level analyses examining iSC preparatory activity just before generation of SRT-matched saccades. When matched for SRTs, we observed no change during FEF inactivation in the relationship between iSC preparatory activity and SRT-matched saccades across a range of SRTs, even for the occasional express saccade. Thus, while our results emphasize that the FEF has an overall excitatory influence on preparatory activity in the iSC, the communication between the iSC and downstream oculomotor brainstem is unaltered for SRT-matched saccades. Society for Neuroscience 2018-04-17 /pmc/articles/PMC5952303/ /pubmed/29766038 http://dx.doi.org/10.1523/ENEURO.0024-18.2018 Text en Copyright © 2018 Dash et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Dash, Suryadeep Peel, Tyler R. Lomber, Stephen G. Corneil, Brian D. Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency |
title | Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency |
title_full | Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency |
title_fullStr | Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency |
title_full_unstemmed | Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency |
title_short | Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency |
title_sort | frontal eye field inactivation reduces saccade preparation in the superior colliculus but does not alter how preparatory activity relates to saccades of a given latency |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952303/ https://www.ncbi.nlm.nih.gov/pubmed/29766038 http://dx.doi.org/10.1523/ENEURO.0024-18.2018 |
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