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Adipose-derived stem cells for treatment of chronic ulcers: current status
Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summari...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952370/ https://www.ncbi.nlm.nih.gov/pubmed/29764508 http://dx.doi.org/10.1186/s13287-018-0887-0 |
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author | Holm, Jens Selch Toyserkani, Navid Mohamadpour Sorensen, Jens Ahm |
author_facet | Holm, Jens Selch Toyserkani, Navid Mohamadpour Sorensen, Jens Ahm |
author_sort | Holm, Jens Selch |
collection | PubMed |
description | Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov. A total of nine clinical trials and fourteen registered trials were included. The studies were significantly different in terms of study design and patient population, and the overall quality of the studies was low to moderate. Despite the overall low study quality and the significant differences between the studies, some conclusions were consistent: ADSCs are safe, improve the healing of chronic ulcers, and reduce pain. As these results are consistent despite the shortcomings of the studies, they appear to highlight the efficacy of ADSCs in the treatment of chronic ulcers. Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers. |
format | Online Article Text |
id | pubmed-5952370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59523702018-05-21 Adipose-derived stem cells for treatment of chronic ulcers: current status Holm, Jens Selch Toyserkani, Navid Mohamadpour Sorensen, Jens Ahm Stem Cell Res Ther Review Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov. A total of nine clinical trials and fourteen registered trials were included. The studies were significantly different in terms of study design and patient population, and the overall quality of the studies was low to moderate. Despite the overall low study quality and the significant differences between the studies, some conclusions were consistent: ADSCs are safe, improve the healing of chronic ulcers, and reduce pain. As these results are consistent despite the shortcomings of the studies, they appear to highlight the efficacy of ADSCs in the treatment of chronic ulcers. Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers. BioMed Central 2018-05-15 /pmc/articles/PMC5952370/ /pubmed/29764508 http://dx.doi.org/10.1186/s13287-018-0887-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Holm, Jens Selch Toyserkani, Navid Mohamadpour Sorensen, Jens Ahm Adipose-derived stem cells for treatment of chronic ulcers: current status |
title | Adipose-derived stem cells for treatment of chronic ulcers: current status |
title_full | Adipose-derived stem cells for treatment of chronic ulcers: current status |
title_fullStr | Adipose-derived stem cells for treatment of chronic ulcers: current status |
title_full_unstemmed | Adipose-derived stem cells for treatment of chronic ulcers: current status |
title_short | Adipose-derived stem cells for treatment of chronic ulcers: current status |
title_sort | adipose-derived stem cells for treatment of chronic ulcers: current status |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952370/ https://www.ncbi.nlm.nih.gov/pubmed/29764508 http://dx.doi.org/10.1186/s13287-018-0887-0 |
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