Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes

Transcription factor 7-like 2 (TCF7L2) is the main susceptibility gene for type 2 diabetes, primarily through impairing the insulin secretion by pancreatic β cells. However, the exact in vivo mechanisms remain poorly understood. We performed a family study and determined if the T risk allele of the...

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Detalles Bibliográficos
Autores principales: Jainandunsing, Sjaam, Koole, H. Rita, van Miert, Joram N.I., Rietveld, Trinet, Wattimena, J.L. Darcos, Sijbrands, Eric J.G., de Rooij, Felix W.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952407/
https://www.ncbi.nlm.nih.gov/pubmed/29631902
http://dx.doi.org/10.1016/j.ebiom.2018.03.026

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