A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters

Despite recent advances, the direct Fmoc-based solid phase synthesis of peptide α-thioesters for the convergent synthesis of proteins via native chemical ligation (NCL) remains a challenge in the field. We herein report a simple and general methodology, enabling access to peptide thioester surrogate...

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Detalles Bibliográficos
Autores principales: Terrier, Victor P., Adihou, Hélène, Arnould, Mathieu, Delmas, Agnès F., Aucagne, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952550/
https://www.ncbi.nlm.nih.gov/pubmed/29861986
http://dx.doi.org/10.1039/c5sc02630j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952550/
https://www.ncbi.nlm.nih.gov/pubmed/29861986
http://dx.doi.org/10.1039/c5sc02630j

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