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A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters
Despite recent advances, the direct Fmoc-based solid phase synthesis of peptide α-thioesters for the convergent synthesis of proteins via native chemical ligation (NCL) remains a challenge in the field. We herein report a simple and general methodology, enabling access to peptide thioester surrogate...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952550/ https://www.ncbi.nlm.nih.gov/pubmed/29861986 http://dx.doi.org/10.1039/c5sc02630j |