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Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature

Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tole...

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Detalles Bibliográficos
Autores principales: Mukherjee, Subhajit, Jana, Tanima, Pan, Jen-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952557/
https://www.ncbi.nlm.nih.gov/pubmed/29854491
http://dx.doi.org/10.1155/2018/4294805
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author Mukherjee, Subhajit
Jana, Tanima
Pan, Jen-Jung
author_facet Mukherjee, Subhajit
Jana, Tanima
Pan, Jen-Jung
author_sort Mukherjee, Subhajit
collection PubMed
description Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study. In this case report, we describe a case of PPI-induced thrombocytopenia. In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation. The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction. Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia.
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spelling pubmed-59525572018-05-31 Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature Mukherjee, Subhajit Jana, Tanima Pan, Jen-Jung Case Rep Gastrointest Med Case Report Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study. In this case report, we describe a case of PPI-induced thrombocytopenia. In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation. The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction. Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia. Hindawi 2018-04-30 /pmc/articles/PMC5952557/ /pubmed/29854491 http://dx.doi.org/10.1155/2018/4294805 Text en Copyright © 2018 Subhajit Mukherjee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mukherjee, Subhajit
Jana, Tanima
Pan, Jen-Jung
Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
title Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
title_full Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
title_fullStr Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
title_full_unstemmed Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
title_short Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
title_sort adverse effects of proton pump inhibitors on platelet count: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952557/
https://www.ncbi.nlm.nih.gov/pubmed/29854491
http://dx.doi.org/10.1155/2018/4294805
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