MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury

Schwann cells (SCs) contribute to nerve repair following injury; however, the underlying molecular mechanism is poorly understood. MicroRNAs (miRNAs), which are short noncoding RNAs, have been shown to play a role in neuronal disease. In this work, we show that miRNAs regulate the peripheral nerve s...

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Detalles Bibliográficos
Autores principales: Sohn, Eun Jung, Park, Hwan Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952561/
https://www.ncbi.nlm.nih.gov/pubmed/29854793
http://dx.doi.org/10.1155/2018/8198365
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author Sohn, Eun Jung
Park, Hwan Tae
author_facet Sohn, Eun Jung
Park, Hwan Tae
author_sort Sohn, Eun Jung
collection PubMed
description Schwann cells (SCs) contribute to nerve repair following injury; however, the underlying molecular mechanism is poorly understood. MicroRNAs (miRNAs), which are short noncoding RNAs, have been shown to play a role in neuronal disease. In this work, we show that miRNAs regulate the peripheral nerve system by modulating the migration and proliferation of SCs. Thus, miRNAs expressed in peripheral nerves may provide a potential therapeutic target for peripheral nerve injury or repair.
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spelling pubmed-59525612018-05-31 MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury Sohn, Eun Jung Park, Hwan Tae Biomed Res Int Review Article Schwann cells (SCs) contribute to nerve repair following injury; however, the underlying molecular mechanism is poorly understood. MicroRNAs (miRNAs), which are short noncoding RNAs, have been shown to play a role in neuronal disease. In this work, we show that miRNAs regulate the peripheral nerve system by modulating the migration and proliferation of SCs. Thus, miRNAs expressed in peripheral nerves may provide a potential therapeutic target for peripheral nerve injury or repair. Hindawi 2018-04-30 /pmc/articles/PMC5952561/ /pubmed/29854793 http://dx.doi.org/10.1155/2018/8198365 Text en Copyright © 2018 Eun Jung Sohn and Hwan Tae Park. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sohn, Eun Jung
Park, Hwan Tae
MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury
title MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury
title_full MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury
title_fullStr MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury
title_full_unstemmed MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury
title_short MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury
title_sort microrna mediated regulation of schwann cell migration and proliferation in peripheral nerve injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952561/
https://www.ncbi.nlm.nih.gov/pubmed/29854793
http://dx.doi.org/10.1155/2018/8198365
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