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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation

OBJECTIVE: Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are man...

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Autores principales: Gomaa, Asmaa Ibrahim, Ehsan, Nermine Ahmed, Elrefaei, Ahmed A., Sultan, Mervat Mohamed, Elsabaawy, Maha Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952568/
https://www.ncbi.nlm.nih.gov/pubmed/29854831
http://dx.doi.org/10.1155/2018/2726939
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author Gomaa, Asmaa Ibrahim
Ehsan, Nermine Ahmed
Elrefaei, Ahmed A.
Sultan, Mervat Mohamed
Elsabaawy, Maha Mohamed
author_facet Gomaa, Asmaa Ibrahim
Ehsan, Nermine Ahmed
Elrefaei, Ahmed A.
Sultan, Mervat Mohamed
Elsabaawy, Maha Mohamed
author_sort Gomaa, Asmaa Ibrahim
collection PubMed
description OBJECTIVE: Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. METHODS: Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study. The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined. RESULTS: CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P < 0.001) than in ACR (P = 0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P = 0.001). CONCLUSION: Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b.
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spelling pubmed-59525682018-05-31 The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation Gomaa, Asmaa Ibrahim Ehsan, Nermine Ahmed Elrefaei, Ahmed A. Sultan, Mervat Mohamed Elsabaawy, Maha Mohamed J Immunol Res Research Article OBJECTIVE: Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. METHODS: Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study. The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined. RESULTS: CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P < 0.001) than in ACR (P = 0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P = 0.001). CONCLUSION: Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b. Hindawi 2018-04-30 /pmc/articles/PMC5952568/ /pubmed/29854831 http://dx.doi.org/10.1155/2018/2726939 Text en Copyright © 2018 Asmaa Ibrahim Gomaa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gomaa, Asmaa Ibrahim
Ehsan, Nermine Ahmed
Elrefaei, Ahmed A.
Sultan, Mervat Mohamed
Elsabaawy, Maha Mohamed
The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
title The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
title_full The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
title_fullStr The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
title_full_unstemmed The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
title_short The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
title_sort role of monocyte/macrophage and cxcr3 in differentiation between recurrent hepatitis c and acute cellular rejection postliver transplantation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952568/
https://www.ncbi.nlm.nih.gov/pubmed/29854831
http://dx.doi.org/10.1155/2018/2726939
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