Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium

BACKGROUND: The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium. METHODS: One hundred and forty-one eyes from 130 patients with primary pterygium were t...

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Autores principales: Pan, Xin, Zhang, Daguang, Jia, Zhifang, Chen, Zhehui, Su, Yuetian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952845/
https://www.ncbi.nlm.nih.gov/pubmed/29764389
http://dx.doi.org/10.1186/s12886-018-0784-4
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author Pan, Xin
Zhang, Daguang
Jia, Zhifang
Chen, Zhehui
Su, Yuetian
author_facet Pan, Xin
Zhang, Daguang
Jia, Zhifang
Chen, Zhehui
Su, Yuetian
author_sort Pan, Xin
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium. METHODS: One hundred and forty-one eyes from 130 patients with primary pterygium were treated with excision followed by hyperdry amniotic membrane or conjunctival autografting after random selection. Seventy-nine eyes from 71 patients received hyperdry amniotic membrane transplantation (HD-AM group), and 62 eyes from 59 patients received conjunctival autografting (CG group). Patients were followed up at one week and one, three, six, and 12 months post-surgery. Recurrence rate, postoperative complications, and final follow-up patient visits were prospectively evaluated. RESULTS: The mean follow-up duration was 12.56 ± 4.35 months in the HD-AM group and 12.85 ± 3.90 months in the CG group. Recurrences were detected in four eyes (5.06%) in the HD-AM group and 13 eyes (20.97%) in the CG group. A statistically significant difference in frequency of recurrence between the two groups (P = 0.003) was observed. The cumulative non-recurrence rates at six and 12 months in all patients stratified by age and sex were not significantly different (P = 0.642 and P = 0.451, respectively, by log-rank test). Graft retraction and necrosis were not detected in the two groups during the follow-up period. CONCLUSION: Hyperdry amniotic membrane transplantation was effective in preventing pterygium recurrence when compared with conjunctival autografting and can be considered a preferable and safe grafting procedure for primary pterygium. TRIAL REGISTRATION: Current Controlled Trials ISRCTN16900270, Retrospectively registered (Date of registration: 3 May 2018).
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spelling pubmed-59528452018-05-21 Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium Pan, Xin Zhang, Daguang Jia, Zhifang Chen, Zhehui Su, Yuetian BMC Ophthalmol Research Article BACKGROUND: The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium. METHODS: One hundred and forty-one eyes from 130 patients with primary pterygium were treated with excision followed by hyperdry amniotic membrane or conjunctival autografting after random selection. Seventy-nine eyes from 71 patients received hyperdry amniotic membrane transplantation (HD-AM group), and 62 eyes from 59 patients received conjunctival autografting (CG group). Patients were followed up at one week and one, three, six, and 12 months post-surgery. Recurrence rate, postoperative complications, and final follow-up patient visits were prospectively evaluated. RESULTS: The mean follow-up duration was 12.56 ± 4.35 months in the HD-AM group and 12.85 ± 3.90 months in the CG group. Recurrences were detected in four eyes (5.06%) in the HD-AM group and 13 eyes (20.97%) in the CG group. A statistically significant difference in frequency of recurrence between the two groups (P = 0.003) was observed. The cumulative non-recurrence rates at six and 12 months in all patients stratified by age and sex were not significantly different (P = 0.642 and P = 0.451, respectively, by log-rank test). Graft retraction and necrosis were not detected in the two groups during the follow-up period. CONCLUSION: Hyperdry amniotic membrane transplantation was effective in preventing pterygium recurrence when compared with conjunctival autografting and can be considered a preferable and safe grafting procedure for primary pterygium. TRIAL REGISTRATION: Current Controlled Trials ISRCTN16900270, Retrospectively registered (Date of registration: 3 May 2018). BioMed Central 2018-05-15 /pmc/articles/PMC5952845/ /pubmed/29764389 http://dx.doi.org/10.1186/s12886-018-0784-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Pan, Xin
Zhang, Daguang
Jia, Zhifang
Chen, Zhehui
Su, Yuetian
Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
title Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
title_full Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
title_fullStr Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
title_full_unstemmed Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
title_short Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
title_sort comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952845/
https://www.ncbi.nlm.nih.gov/pubmed/29764389
http://dx.doi.org/10.1186/s12886-018-0784-4
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