Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium
BACKGROUND: The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium. METHODS: One hundred and forty-one eyes from 130 patients with primary pterygium were t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952845/ https://www.ncbi.nlm.nih.gov/pubmed/29764389 http://dx.doi.org/10.1186/s12886-018-0784-4 |
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author | Pan, Xin Zhang, Daguang Jia, Zhifang Chen, Zhehui Su, Yuetian |
author_facet | Pan, Xin Zhang, Daguang Jia, Zhifang Chen, Zhehui Su, Yuetian |
author_sort | Pan, Xin |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium. METHODS: One hundred and forty-one eyes from 130 patients with primary pterygium were treated with excision followed by hyperdry amniotic membrane or conjunctival autografting after random selection. Seventy-nine eyes from 71 patients received hyperdry amniotic membrane transplantation (HD-AM group), and 62 eyes from 59 patients received conjunctival autografting (CG group). Patients were followed up at one week and one, three, six, and 12 months post-surgery. Recurrence rate, postoperative complications, and final follow-up patient visits were prospectively evaluated. RESULTS: The mean follow-up duration was 12.56 ± 4.35 months in the HD-AM group and 12.85 ± 3.90 months in the CG group. Recurrences were detected in four eyes (5.06%) in the HD-AM group and 13 eyes (20.97%) in the CG group. A statistically significant difference in frequency of recurrence between the two groups (P = 0.003) was observed. The cumulative non-recurrence rates at six and 12 months in all patients stratified by age and sex were not significantly different (P = 0.642 and P = 0.451, respectively, by log-rank test). Graft retraction and necrosis were not detected in the two groups during the follow-up period. CONCLUSION: Hyperdry amniotic membrane transplantation was effective in preventing pterygium recurrence when compared with conjunctival autografting and can be considered a preferable and safe grafting procedure for primary pterygium. TRIAL REGISTRATION: Current Controlled Trials ISRCTN16900270, Retrospectively registered (Date of registration: 3 May 2018). |
format | Online Article Text |
id | pubmed-5952845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59528452018-05-21 Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium Pan, Xin Zhang, Daguang Jia, Zhifang Chen, Zhehui Su, Yuetian BMC Ophthalmol Research Article BACKGROUND: The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium. METHODS: One hundred and forty-one eyes from 130 patients with primary pterygium were treated with excision followed by hyperdry amniotic membrane or conjunctival autografting after random selection. Seventy-nine eyes from 71 patients received hyperdry amniotic membrane transplantation (HD-AM group), and 62 eyes from 59 patients received conjunctival autografting (CG group). Patients were followed up at one week and one, three, six, and 12 months post-surgery. Recurrence rate, postoperative complications, and final follow-up patient visits were prospectively evaluated. RESULTS: The mean follow-up duration was 12.56 ± 4.35 months in the HD-AM group and 12.85 ± 3.90 months in the CG group. Recurrences were detected in four eyes (5.06%) in the HD-AM group and 13 eyes (20.97%) in the CG group. A statistically significant difference in frequency of recurrence between the two groups (P = 0.003) was observed. The cumulative non-recurrence rates at six and 12 months in all patients stratified by age and sex were not significantly different (P = 0.642 and P = 0.451, respectively, by log-rank test). Graft retraction and necrosis were not detected in the two groups during the follow-up period. CONCLUSION: Hyperdry amniotic membrane transplantation was effective in preventing pterygium recurrence when compared with conjunctival autografting and can be considered a preferable and safe grafting procedure for primary pterygium. TRIAL REGISTRATION: Current Controlled Trials ISRCTN16900270, Retrospectively registered (Date of registration: 3 May 2018). BioMed Central 2018-05-15 /pmc/articles/PMC5952845/ /pubmed/29764389 http://dx.doi.org/10.1186/s12886-018-0784-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Pan, Xin Zhang, Daguang Jia, Zhifang Chen, Zhehui Su, Yuetian Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
title | Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
title_full | Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
title_fullStr | Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
title_full_unstemmed | Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
title_short | Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
title_sort | comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952845/ https://www.ncbi.nlm.nih.gov/pubmed/29764389 http://dx.doi.org/10.1186/s12886-018-0784-4 |
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