Cargando…
Early detection of ulcerative colitis-associated colorectal cancer
Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality t...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952942/ https://www.ncbi.nlm.nih.gov/pubmed/29780595 http://dx.doi.org/10.1093/gastro/goy010 |
_version_ | 1783323287168745472 |
---|---|
author | Zhen, Yu Luo, Chengxin Zhang, Hu |
author_facet | Zhen, Yu Luo, Chengxin Zhang, Hu |
author_sort | Zhen, Yu |
collection | PubMed |
description | Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality than sporadic colorectal cancer, early detection is critical. Colonoscopy is primarily recommended for surveillance and several advanced endoscopic imaging techniques are emerging. In addition, recent studies have reported on attempts to develop clinically relevant biomarkers for surveillance using various biosamples, which may become high-performance screening tools in the future, so the best approach and technique for cancer surveillance in long-standing UC patients remain under debate. This review gives a comprehensive description and summary about what progress has been made in terms of early CACC detection. |
format | Online Article Text |
id | pubmed-5952942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59529422018-05-18 Early detection of ulcerative colitis-associated colorectal cancer Zhen, Yu Luo, Chengxin Zhang, Hu Gastroenterol Rep (Oxf) Review Articles Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality than sporadic colorectal cancer, early detection is critical. Colonoscopy is primarily recommended for surveillance and several advanced endoscopic imaging techniques are emerging. In addition, recent studies have reported on attempts to develop clinically relevant biomarkers for surveillance using various biosamples, which may become high-performance screening tools in the future, so the best approach and technique for cancer surveillance in long-standing UC patients remain under debate. This review gives a comprehensive description and summary about what progress has been made in terms of early CACC detection. Oxford University Press 2018-05 2018-05-14 /pmc/articles/PMC5952942/ /pubmed/29780595 http://dx.doi.org/10.1093/gastro/goy010 Text en © The Author(s) 2018. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-Sen University http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Review Articles Zhen, Yu Luo, Chengxin Zhang, Hu Early detection of ulcerative colitis-associated colorectal cancer |
title | Early detection of ulcerative colitis-associated colorectal cancer |
title_full | Early detection of ulcerative colitis-associated colorectal cancer |
title_fullStr | Early detection of ulcerative colitis-associated colorectal cancer |
title_full_unstemmed | Early detection of ulcerative colitis-associated colorectal cancer |
title_short | Early detection of ulcerative colitis-associated colorectal cancer |
title_sort | early detection of ulcerative colitis-associated colorectal cancer |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952942/ https://www.ncbi.nlm.nih.gov/pubmed/29780595 http://dx.doi.org/10.1093/gastro/goy010 |
work_keys_str_mv | AT zhenyu earlydetectionofulcerativecolitisassociatedcolorectalcancer AT luochengxin earlydetectionofulcerativecolitisassociatedcolorectalcancer AT zhanghu earlydetectionofulcerativecolitisassociatedcolorectalcancer |