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Early detection of ulcerative colitis-associated colorectal cancer

Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality t...

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Detalles Bibliográficos
Autores principales: Zhen, Yu, Luo, Chengxin, Zhang, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952942/
https://www.ncbi.nlm.nih.gov/pubmed/29780595
http://dx.doi.org/10.1093/gastro/goy010
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author Zhen, Yu
Luo, Chengxin
Zhang, Hu
author_facet Zhen, Yu
Luo, Chengxin
Zhang, Hu
author_sort Zhen, Yu
collection PubMed
description Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality than sporadic colorectal cancer, early detection is critical. Colonoscopy is primarily recommended for surveillance and several advanced endoscopic imaging techniques are emerging. In addition, recent studies have reported on attempts to develop clinically relevant biomarkers for surveillance using various biosamples, which may become high-performance screening tools in the future, so the best approach and technique for cancer surveillance in long-standing UC patients remain under debate. This review gives a comprehensive description and summary about what progress has been made in terms of early CACC detection.
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spelling pubmed-59529422018-05-18 Early detection of ulcerative colitis-associated colorectal cancer Zhen, Yu Luo, Chengxin Zhang, Hu Gastroenterol Rep (Oxf) Review Articles Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality than sporadic colorectal cancer, early detection is critical. Colonoscopy is primarily recommended for surveillance and several advanced endoscopic imaging techniques are emerging. In addition, recent studies have reported on attempts to develop clinically relevant biomarkers for surveillance using various biosamples, which may become high-performance screening tools in the future, so the best approach and technique for cancer surveillance in long-standing UC patients remain under debate. This review gives a comprehensive description and summary about what progress has been made in terms of early CACC detection. Oxford University Press 2018-05 2018-05-14 /pmc/articles/PMC5952942/ /pubmed/29780595 http://dx.doi.org/10.1093/gastro/goy010 Text en © The Author(s) 2018. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-Sen University http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review Articles
Zhen, Yu
Luo, Chengxin
Zhang, Hu
Early detection of ulcerative colitis-associated colorectal cancer
title Early detection of ulcerative colitis-associated colorectal cancer
title_full Early detection of ulcerative colitis-associated colorectal cancer
title_fullStr Early detection of ulcerative colitis-associated colorectal cancer
title_full_unstemmed Early detection of ulcerative colitis-associated colorectal cancer
title_short Early detection of ulcerative colitis-associated colorectal cancer
title_sort early detection of ulcerative colitis-associated colorectal cancer
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952942/
https://www.ncbi.nlm.nih.gov/pubmed/29780595
http://dx.doi.org/10.1093/gastro/goy010
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