A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

The selectivity of an enzyme inhibitor is a key determinant of its usefulness as a tool compound or its safety as a drug. Yet selectivity is never assessed comprehensively in the early stages of the drug discovery process, and only rarely even in the later stages, because technical limitations prohi...

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Detalles Bibliográficos
Autores principales: Bachovchin, Daniel A., Koblan, Luke W., Wu, Wengen, Liu, Yuxin, Li, Youhua, Zhao, Peng, Woznica, Iwona, Shu, Ying, Lai, Jack H., Poplawski, Sarah E., Kiritsy, Christopher P., Healey, Sarah E., DiMare, Matthew, Sanford, David G., Munford, Robert S., Bachovchin, William W., Golub, Todd R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953424/
https://www.ncbi.nlm.nih.gov/pubmed/24997602
http://dx.doi.org/10.1038/nchembio.1578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953424/
https://www.ncbi.nlm.nih.gov/pubmed/24997602
http://dx.doi.org/10.1038/nchembio.1578

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