Cargando…

Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

Although the human gut microbiome plays a prominent role in xenobiotic transformation, most of the genes and enzymes responsible for this metabolism are unknown. Recently, we linked the two-gene ‘cardiac glycoside reductase’ (cgr) operon encoded by the gut Actinobacterium Eggerthella lenta to inacti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koppel, Nitzan, Bisanz, Jordan E, Pandelia, Maria-Eirini, Turnbaugh, Peter J, Balskus, Emily P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953540/ https://www.ncbi.nlm.nih.gov/pubmed/29761785 http://dx.doi.org/10.7554/eLife.33953

Ejemplares similares

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
por: Rekdal, Vayu Maini, et al.
Publicado: (2019)

The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
por: Ang, Qi Yan, et al.
Publicado: (2021)

Chemical transformation of xenobiotics by the human gut microbiota
por: Koppel, Nitzan, et al.
Publicado: (2018)

Gut bacterial aggregates as living gels
por: Schlomann, Brandon H, et al.
Publicado: (2021)

Epidemiology and Characterization of Shiga Toxin-Producing Escherichia Coli of Hemolytic Uremic Syndrome in Argentina
por: Torti, Jeronimo F, et al.
Publicado: (2021)

Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in healthy individuals: protocol for a systematic review and meta-analysis
por: Li, Mao, et al.
Publicado: (2021)

An Evaluation of the Bacterial Adherence to Casting Materials
por: Massaglia, Joseph E, et al.
Publicado: (2021)

Nanosecond pulsed electric field (nsPEF) and vaccines: a novel technique for the inactivation of SARS-CoV-2 and other viruses?
por: Ruiz-Fernández, A. R., et al.
Publicado: (2022)

From the Gut to the Heart: Campylobacter jejuni Enteritis Leading to Myopericarditis
por: Inayat, Faisal, et al.
Publicado: (2017)

Performance of commercial tests for molecular detection of Shiga toxin-producing Escherichia coli (STEC): a systematic review and meta-analysis protocol
por: Tarr, Gillian A M, et al.
Publicado: (2019)

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
por: Sampson, Timothy R, et al.
Publicado: (2020)

Splenic Abscess: A Rare Complication of Bacterial Pneumonia
por: Owolabi, Modupeoluwa, et al.
Publicado: (2023)

Secondary Bacterial Infection Rates Among Patients With COVID-19
por: Bahceci, Ilkay, et al.
Publicado: (2022)

When Influenza, Bacterial Pneumonia, and COVID-19 Co-exist
por: Owolabi, Modupeoluwa, et al.
Publicado: (2022)

Effectiveness of inactivated COVID-19 vaccines against SARS-CoV-2 infections among healthcare personnel in Pakistan: a test-negative case–control study
por: Khan, Unab Inayat, et al.
Publicado: (2023)

Is Fever a Red Flag for Bacterial Pneumonia in Children With Viral Bronchiolitis?
por: Elmore, Dominique, et al.
Publicado: (2019)

Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname
por: Zonneveld, Rens, et al.
Publicado: (2018)

In vitro and in silico studies on clinically important enzymes inhibitory activities of flavonoids isolated from Euphorbia pulcherrima
por: Rauf, Abdur, et al.
Publicado: (2022)

Disease severity of Shiga toxin-producing E. coli O157 and factors influencing the development of typical haemolytic uraemic syndrome: a retrospective cohort study, 2009–2012
por: Launders, N, et al.
Publicado: (2016)

Differential diagnosis of pandemic (H1N1) 2009 infection by detection of haemagglutinin with an enzyme‐linked immunoassay
por: Yuan, Q., et al.
Publicado: (2011)

Apoptosis levels in bovine Johne’s disease ileal lesions and association with bacterial numbers
por: Lucena, Amalia Naranjo-, et al.
Publicado: (2021)

Bacterial Colonization in Double J Stent and Bacteriuria in Post-Renal Transplant Patients
por: Abu, Sadiq, et al.
Publicado: (2022)

Isolation of Patients With Bacterial Pneumonia Suspected of COVID-19 Leads to Prolonged Hospitalization
por: Tamura, Akiko, et al.
Publicado: (2022)

Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults
por: Ader, Florence
Publicado: (2020)

Bacterial Colony: First Report of Donut Colony Morphology among Diphtheroids Isolated in Blood
por: Kandi, Venkataramana
Publicado: (2015)

Impact of bacterial colonization on the severity, and accompanying airway inflammation, of virus‐induced wheezing in children
por: Yu, D., et al.
Publicado: (2010)

Piperacillin–tazobactam versus meropenem for treatment of bloodstream infections caused by third-generation cephalosporin-resistant Enterobacteriaceae: a study protocol for a non-inferiority open-label randomised controlled trial (PeterPen)
por: Bitterman, Roni, et al.
Publicado: (2021)

Is there a role of faecal microbiota transplantation in reducing antibiotic resistance burden in gut? A systematic review and Meta-analysis
por: Dharmaratne, Priyanga, et al.
Publicado: (2021)

Risk factors and prognosis of seizures in adults with community-acquired bacterial meningitis in Denmark: observational cohort studies
por: Larsen, Fredrikke Tove Birgitta Dam, et al.
Publicado: (2019)

Early and Appropriate Use of Ceftazidime-Avibactam in the Management of Multidrug-Resistant Gram-Negative Bacterial Infections in the Indian Scenario
por: Swaminathan, Subramanian, et al.
Publicado: (2022)

Epidemiology of bacterial co-infections and risk factors in COVID-19-hospitalized patients in Spain: a nationwide study
por: López-Herrero, R, et al.
Publicado: (2023)

Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics
por: Haiser, Henry J, et al.
Publicado: (2014)

Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study
por: Labout, Joost A. M., et al.
Publicado: (2010)

Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: a prospective study
por: Ye, Y, et al.
Publicado: (2013)

A cross-sectional study on the relationship of age, gestational age and HIV infection to bacterial vaginosis and genital mycoplasma infection
por: Redelinghuys, Mathys J, et al.
Publicado: (2015)

Discordance of the Urinary and Pleural Fluid Antigen Test and False Positive for Streptococcus pneumoniae in Empyema Secondary to Necrotizing Bacterial Pneumonia
por: Shumway, David O, et al.
Publicado: (2023)

Surgical Site Bacterial Infection in a General Hospital, Al-Jouf Region, Saudi Arabia: A Retrospective Study
por: Al-Khalidi, Suliman, et al.
Publicado: (2023)

Prevalence of respiratory bacterial infections in people with lower respiratory tract infections in Africa: the BARIAFRICA systematic review and meta-analysis protocol
por: Tchatchouang, Serges, et al.
Publicado: (2018)

An In Vitro Susceptibility Study of Cefotaxime-Sulbactam on Clinical Bacterial Isolates From Various Regions in India: A Comparison With Ceftriaxone-Sulbactam
por: Gondane, Ajitkumar A, et al.
Publicado: (2023)

Bacterial antibiotic resistance development and mutagenesis following exposure to subminimal inhibitory concentrations of fluoroquinolones in vitro: a systematic literature review protocol
por: Ching, Carly, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6smisrr9lh9adcv52vpd020tti