From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development

The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their p...

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Detalles Bibliográficos
Autores principales: van Tuyl, Minke, Post, Martin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59539/
https://www.ncbi.nlm.nih.gov/pubmed/11667962
http://dx.doi.org/10.1186/rr9
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author van Tuyl, Minke
Post, Martin
author_facet van Tuyl, Minke
Post, Martin
author_sort van Tuyl, Minke
collection PubMed
description The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling.
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spelling pubmed-595392001-11-06 From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development van Tuyl, Minke Post, Martin Respir Res Review The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling. BioMed Central 2000 2000-06-20 /pmc/articles/PMC59539/ /pubmed/11667962 http://dx.doi.org/10.1186/rr9 Text en Copyright © 2000 Current Science Ltd
spellingShingle Review
van Tuyl, Minke
Post, Martin
From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
title From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
title_full From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
title_fullStr From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
title_full_unstemmed From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
title_short From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
title_sort from fruitflies to mammals: mechanisms of signalling via the sonic hedgehog pathway in lung development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59539/
https://www.ncbi.nlm.nih.gov/pubmed/11667962
http://dx.doi.org/10.1186/rr9
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