Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that homozygous knock-in mice carrying a point mutation at the...

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Detalles Bibliográficos
Autores principales: Li, Terytty Yang, Song, Lintao, Sun, Yu, Li, Jingyi, Yi, Cong, Lam, Sin Man, Xu, Dijin, Zhou, Linkang, Li, Xiaotong, Yang, Ying, Zhang, Chen-Song, Xie, Changchuan, Huang, Xi, Shui, Guanghou, Lin, Shu-Yong, Reue, Karen, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953937/
https://www.ncbi.nlm.nih.gov/pubmed/29765047
http://dx.doi.org/10.1038/s41467-018-04363-w

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