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Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma

PURPOSE: Metabolic tumour volume (MTV) is a promising prognostic indicator in diffuse large B cell lymphoma (DLBCL). Optimal thresholds to divide patients into ‘low’ versus ‘high’ MTV groups depend on clinical characteristics and the measurement method. The aim of this study was to compare in consec...

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Autores principales: Ilyas, Hajira, Mikhaeel, N. George, Dunn, Joel T., Rahman, Fareen, Møller, Henrik, Smith, Daniel, Barrington, Sally F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953976/
https://www.ncbi.nlm.nih.gov/pubmed/29460024
http://dx.doi.org/10.1007/s00259-018-3953-z
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author Ilyas, Hajira
Mikhaeel, N. George
Dunn, Joel T.
Rahman, Fareen
Møller, Henrik
Smith, Daniel
Barrington, Sally F.
author_facet Ilyas, Hajira
Mikhaeel, N. George
Dunn, Joel T.
Rahman, Fareen
Møller, Henrik
Smith, Daniel
Barrington, Sally F.
author_sort Ilyas, Hajira
collection PubMed
description PURPOSE: Metabolic tumour volume (MTV) is a promising prognostic indicator in diffuse large B cell lymphoma (DLBCL). Optimal thresholds to divide patients into ‘low’ versus ‘high’ MTV groups depend on clinical characteristics and the measurement method. The aim of this study was to compare in consecutive unselected patients with DLBCL, different software algorithms and published methods of MTV measurement using FDG PET. METHOD: Pretreatment MTV was measured on 147 patients treated at Guy's and St Thomas’ Hospital. We compared 3 methods: SUV ≥2.5, SUV ≥41% of maximum SUV and SUV ≥ mean liver uptake (PERCIST) and compared 2 software programs for measuring SUV ≥2.5; in-house ‘PETTRA’ software and Hermes commercial software. RESULTS: There was strong correlation between MTV using the 4 methods, although derived thresholds were very different for the 41% method. Optimal cut-offs for predicting PFS ranged from 166–400cm(3). All methods predicted survival with similar accuracy. 5y-PFS was 83–87% vs. 42–44% and 5y-OS was 85–89% vs. 55–58% for the low- and high-MTV groups, respectively. Interobserver variation in 50 patients showed excellent agreement, though variation was lowest using the SUV ≥ 2.5 method. The 41% method was the most complex and took the longest time. CONCLUSION: All methods predicted PFS and OS with similar accuracy, but the derived cut-off separating good from poor prognosis varied markedly depending on the method. The choice of the optimal method should rely primarily on prognostic value, but for clinical use needs to take account of ease of use and reproducibility. In this study, all methods predicted prognosis, but SUV ≥ 2.5 had the best inter-observer agreement and was easiest to apply.
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spelling pubmed-59539762018-05-18 Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma Ilyas, Hajira Mikhaeel, N. George Dunn, Joel T. Rahman, Fareen Møller, Henrik Smith, Daniel Barrington, Sally F. Eur J Nucl Med Mol Imaging Original Article PURPOSE: Metabolic tumour volume (MTV) is a promising prognostic indicator in diffuse large B cell lymphoma (DLBCL). Optimal thresholds to divide patients into ‘low’ versus ‘high’ MTV groups depend on clinical characteristics and the measurement method. The aim of this study was to compare in consecutive unselected patients with DLBCL, different software algorithms and published methods of MTV measurement using FDG PET. METHOD: Pretreatment MTV was measured on 147 patients treated at Guy's and St Thomas’ Hospital. We compared 3 methods: SUV ≥2.5, SUV ≥41% of maximum SUV and SUV ≥ mean liver uptake (PERCIST) and compared 2 software programs for measuring SUV ≥2.5; in-house ‘PETTRA’ software and Hermes commercial software. RESULTS: There was strong correlation between MTV using the 4 methods, although derived thresholds were very different for the 41% method. Optimal cut-offs for predicting PFS ranged from 166–400cm(3). All methods predicted survival with similar accuracy. 5y-PFS was 83–87% vs. 42–44% and 5y-OS was 85–89% vs. 55–58% for the low- and high-MTV groups, respectively. Interobserver variation in 50 patients showed excellent agreement, though variation was lowest using the SUV ≥ 2.5 method. The 41% method was the most complex and took the longest time. CONCLUSION: All methods predicted PFS and OS with similar accuracy, but the derived cut-off separating good from poor prognosis varied markedly depending on the method. The choice of the optimal method should rely primarily on prognostic value, but for clinical use needs to take account of ease of use and reproducibility. In this study, all methods predicted prognosis, but SUV ≥ 2.5 had the best inter-observer agreement and was easiest to apply. Springer Berlin Heidelberg 2018-02-19 2018 /pmc/articles/PMC5953976/ /pubmed/29460024 http://dx.doi.org/10.1007/s00259-018-3953-z Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Ilyas, Hajira
Mikhaeel, N. George
Dunn, Joel T.
Rahman, Fareen
Møller, Henrik
Smith, Daniel
Barrington, Sally F.
Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma
title Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma
title_full Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma
title_fullStr Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma
title_full_unstemmed Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma
title_short Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma
title_sort defining the optimal method for measuring baseline metabolic tumour volume in diffuse large b cell lymphoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953976/
https://www.ncbi.nlm.nih.gov/pubmed/29460024
http://dx.doi.org/10.1007/s00259-018-3953-z
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