Cargando…
Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study
PURPOSE: Wire localization has several disadvantages, notably wire migration and difficulty scheduling the procedure close to surgery. Radioactive seed localization overcomes these disadvantages, but implementation is limited due to radiation safety requirements. Magnetic seeds potentially offer the...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953977/ https://www.ncbi.nlm.nih.gov/pubmed/29453521 http://dx.doi.org/10.1007/s10549-018-4709-y |
_version_ | 1783323426184757248 |
---|---|
author | Harvey, James R. Lim, Yit Murphy, John Howe, Miles Morris, Julie Goyal, Amit Maxwell, Anthony J. |
author_facet | Harvey, James R. Lim, Yit Murphy, John Howe, Miles Morris, Julie Goyal, Amit Maxwell, Anthony J. |
author_sort | Harvey, James R. |
collection | PubMed |
description | PURPOSE: Wire localization has several disadvantages, notably wire migration and difficulty scheduling the procedure close to surgery. Radioactive seed localization overcomes these disadvantages, but implementation is limited due to radiation safety requirements. Magnetic seeds potentially offer the logistical benefits and transcutaneous detection equivalence of a radioactive seed, with easier implementation. This study was designed to evaluate the feasibility and safety of using magnetic seeds for breast lesion localization. METHODS: A two-centre open-label cohort study to assess the feasibility and safety of magnetic seed (Magseed) localization of breast lesions. Magseeds were placed under radiological guidance into women having total mastectomy surgery. The primary outcome measure was seed migration distance. Secondary outcome measures included accuracy of placement, ease of transcutaneous detection, seed integrity and safety. RESULTS: Twenty-nine Magseeds were placed into the breasts of 28 patients under ultrasound guidance. There was no migration of the seeds between placement and surgery. Twenty-seven seeds were placed directly in the target lesion with the other seeds being 2 and 3 mm away. All seeds were detectable transcutaneously in all breast sizes and at all depths. There were no complications or safety issues. CONCLUSIONS: Magnetic seeds are a feasible and safe method of breast lesion localization. They can be accurately placed, demonstrate no migration in this feasibility study and are detectable in all sizes and depths of breast tissue. Now that safety and feasibility have been demonstrated, further clinical studies are required to evaluate the seed’s effectiveness in wide local excision surgery. |
format | Online Article Text |
id | pubmed-5953977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-59539772018-05-18 Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study Harvey, James R. Lim, Yit Murphy, John Howe, Miles Morris, Julie Goyal, Amit Maxwell, Anthony J. Breast Cancer Res Treat Clinical Trial PURPOSE: Wire localization has several disadvantages, notably wire migration and difficulty scheduling the procedure close to surgery. Radioactive seed localization overcomes these disadvantages, but implementation is limited due to radiation safety requirements. Magnetic seeds potentially offer the logistical benefits and transcutaneous detection equivalence of a radioactive seed, with easier implementation. This study was designed to evaluate the feasibility and safety of using magnetic seeds for breast lesion localization. METHODS: A two-centre open-label cohort study to assess the feasibility and safety of magnetic seed (Magseed) localization of breast lesions. Magseeds were placed under radiological guidance into women having total mastectomy surgery. The primary outcome measure was seed migration distance. Secondary outcome measures included accuracy of placement, ease of transcutaneous detection, seed integrity and safety. RESULTS: Twenty-nine Magseeds were placed into the breasts of 28 patients under ultrasound guidance. There was no migration of the seeds between placement and surgery. Twenty-seven seeds were placed directly in the target lesion with the other seeds being 2 and 3 mm away. All seeds were detectable transcutaneously in all breast sizes and at all depths. There were no complications or safety issues. CONCLUSIONS: Magnetic seeds are a feasible and safe method of breast lesion localization. They can be accurately placed, demonstrate no migration in this feasibility study and are detectable in all sizes and depths of breast tissue. Now that safety and feasibility have been demonstrated, further clinical studies are required to evaluate the seed’s effectiveness in wide local excision surgery. Springer US 2018-02-16 2018 /pmc/articles/PMC5953977/ /pubmed/29453521 http://dx.doi.org/10.1007/s10549-018-4709-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Clinical Trial Harvey, James R. Lim, Yit Murphy, John Howe, Miles Morris, Julie Goyal, Amit Maxwell, Anthony J. Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study |
title | Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study |
title_full | Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study |
title_fullStr | Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study |
title_full_unstemmed | Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study |
title_short | Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study |
title_sort | safety and feasibility of breast lesion localization using magnetic seeds (magseed): a multi-centre, open-label cohort study |
topic | Clinical Trial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953977/ https://www.ncbi.nlm.nih.gov/pubmed/29453521 http://dx.doi.org/10.1007/s10549-018-4709-y |
work_keys_str_mv | AT harveyjamesr safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy AT limyit safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy AT murphyjohn safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy AT howemiles safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy AT morrisjulie safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy AT goyalamit safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy AT maxwellanthonyj safetyandfeasibilityofbreastlesionlocalizationusingmagneticseedsmagseedamulticentreopenlabelcohortstudy |