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Guiding dose adjustment of amlodipine after co-administration with ritonavir containing regimens using a physiologically-based pharmacokinetic/pharmacodynamic model

Amlodipine, a commonly prescribed anti-hypertensive drug, shows increased systemic exposure with cytochrome P450 (CYP) 3A inhibitors. Ritonavir (RTV) is a potent mechanism-based and reversible CYP3A inhibitor and moderate inducer that is used as a pharmacokinetic enhancer in several antiviral treatm...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Dwaipayan, Zha, Jiuhong, Menon, Rajeev M., Shebley, Mohamad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953987/ https://www.ncbi.nlm.nih.gov/pubmed/29427135 http://dx.doi.org/10.1007/s10928-018-9574-0

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