Cargando…

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear. Here, we demonstrate that epithelial–mesenchymal transition (EMT) enriches PD-L1 in CSCs by the EMT/β-catenin/STT3/PD-L1 signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsu, Jung-Mao, Xia, Weiya, Hsu, Yi-Hsin, Chan, Li-Chuan, Yu, Wen-Hsuan, Cha, Jong-Ho, Chen, Chun-Te, Liao, Hsin-Wei, Kuo, Chu-Wei, Khoo, Kay-Hooi, Hsu, Jennifer L., Li, Chia-Wei, Lim, Seung-Oe, Chang, Shih-Shin, Chen, Yi-Chun, Ren, Guo-xin, Hung, Mien-Chie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954021/ https://www.ncbi.nlm.nih.gov/pubmed/29765039 http://dx.doi.org/10.1038/s41467-018-04313-6

Ejemplares similares

STT-DPSA: Digital PUF-Based Secure Authentication Using STT-MRAM for the Internet of Things
por: Chien, Wei-Chen, et al.
Publicado: (2020)

Proteome and Glycoproteome Analyses Reveal the Protein N-Linked Glycosylation Specificity of STT3A and STT3B
por: Wen, Piaopiao, et al.
Publicado: (2022)

Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer
por: Qiu, Yufan, et al.
Publicado: (2021)

STT3B gets the tip
por: Leslie, Mitch
Publicado: (2013)

p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulating miRNAs
por: Chang, Chun-Ju, et al.
Publicado: (2011)

Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites
por: Cherepanova, Natalia A., et al.
Publicado: (2019)

Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis
por: Lau, Poyee, et al.
Publicado: (2022)

Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
por: Deng, Yalan, et al.
Publicado: (2021)

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
por: Li, Chia-Wei, et al.
Publicado: (2016)

Osteoarthritis of the Wrist STT Joint and Radiocarpal Joint
por: Wollstein, Ronit, et al.
Publicado: (2012)

An optimized protocol for PD-L1 pathological assessment with patient sample deglycosylation to improve correlation with therapeutic response
por: Wang, Ying-Nai, et al.
Publicado: (2022)

Prospects of the potential strategies to improve the efficacy of anti‐PD‐1/PD‐L1 therapy
por: Yamaguchi, Hirohito, et al.
Publicado: (2022)

The role of PD-L1 in the radiation response and clinical outcome for bladder cancer
por: Wu, Chun-Te, et al.
Publicado: (2016)

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs
por: Chen, Chia-Hung, et al.
Publicado: (2021)

PD-L1-Mediated Gasdermin C Expression Switches Apoptosis to Pyroptosis in Cancer Cells and Facilitates Tumor Necrosis
por: Hou, Junwei, et al.
Publicado: (2020)

Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion
por: Huang, Hsiang‐Chi, et al.
Publicado: (2023)

Weight Gain Associated with COVID-19 Lockdown in Children and Adolescents: A Systematic Review and Meta-Analysis
por: Chang, Tu-Hsuan, et al.
Publicado: (2021)

Investigation of PVT-Aware STT-MRAM Sensing Circuits for Low-VDD Scenario
por: Bian, Zhongjian, et al.
Publicado: (2021)

Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors
por: Du, Yi, et al.
Publicado: (2016)

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers
por: Ko, How-Wen, et al.
Publicado: (2016)

T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 Streptococcus pyogenes
por: Chen, Yi-Hsuan, et al.
Publicado: (2020)

The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
por: Wang, Ying-Nai, et al.
Publicado: (2020)

Application of mentorship program for another aspect of surgical residency training: The importance of academia in surgical training
por: Chan, Kun-Ming, et al.
Publicado: (2021)

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
por: Yang, Riyao, et al.
Publicado: (2021)

Comparative and evolutionary analyses of the divergence of plant oligosaccharyltransferase STT3 isoforms
por: Niu, Guanting, et al.
Publicado: (2020)

Using Arterial Pulse and Laser Doppler Analyses to Discriminate between the Cardiovascular Effects of Different Running Levels
por: Lin, Yi-Jia, et al.
Publicado: (2023)

Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation
por: Lin, Chun-Yu, et al.
Publicado: (2023)

Association evidence of CCTTT repeat polymorphism in the iNOS promoter and the risk of atrial fibrillation in Taiwanese
por: Hsu, Lung-An, et al.
Publicado: (2017)

Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
por: Luan, Chih-Wei, et al.
Publicado: (2021)

Spin transfer torque (STT) based devices, circuits, and memory
por: Verma, Shivam, et al.
Publicado: (2016)

Activation of phagocytosis by immune checkpoint blockade
por: Li, Chia-Wei, et al.
Publicado: (2018)

Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma
por: Luo, Sheng-Dean, et al.
Publicado: (2022)

Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice
por: Lee, Mon-Chien, et al.
Publicado: (2022)

An improved formula for standard hypoxia tolerance time (STT) to evaluate hypoxic tolerance in mice
por: Xu, Gang, et al.
Publicado: (2018)

Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2
por: Chen, Hsiao-Yun, et al.
Publicado: (2020)

Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
por: Luan, Chih-Wei, et al.
Publicado: (2021)

The Prognostic Significance of PD1 and PDL1 Gene Expression in Lung Cancer: A Meta-Analysis
por: Chang, Chih-Hao, et al.
Publicado: (2021)

MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese
por: Hsiao, Fu-Chih, et al.
Publicado: (2016)

Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex
por: Nilsson, IngMarie, et al.
Publicado: (2003)

Analysis of the Chloroplast Protein Kinase Stt7 during State Transitions
por: Lemeille, Sylvain, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_sj72dnmihbge28n3rqimhmqtul