cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway

The nitric oxide (NO)–protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that...

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Detalles Bibliográficos
Autores principales: Park, Min, Sandner, Peter, Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954070/
https://www.ncbi.nlm.nih.gov/pubmed/29766323
http://dx.doi.org/10.1007/s00395-018-0679-9
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author Park, Min
Sandner, Peter
Krieg, Thomas
author_facet Park, Min
Sandner, Peter
Krieg, Thomas
author_sort Park, Min
collection PubMed
description The nitric oxide (NO)–protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that modulate cGMP and its downstream targets shows very promising results in recent preclinical and clinical studies. Here, we review main aspects of the NO–PKG pathway in light of recent drug development and summarise potential cardioprotective strategies in which cGMP is the main player.
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spelling pubmed-59540702018-05-18 cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway Park, Min Sandner, Peter Krieg, Thomas Basic Res Cardiol Invited Review The nitric oxide (NO)–protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that modulate cGMP and its downstream targets shows very promising results in recent preclinical and clinical studies. Here, we review main aspects of the NO–PKG pathway in light of recent drug development and summarise potential cardioprotective strategies in which cGMP is the main player. Springer Berlin Heidelberg 2018-05-15 2018 /pmc/articles/PMC5954070/ /pubmed/29766323 http://dx.doi.org/10.1007/s00395-018-0679-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Invited Review
Park, Min
Sandner, Peter
Krieg, Thomas
cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
title cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
title_full cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
title_fullStr cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
title_full_unstemmed cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
title_short cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
title_sort cgmp at the centre of attention: emerging strategies for activating the cardioprotective pkg pathway
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954070/
https://www.ncbi.nlm.nih.gov/pubmed/29766323
http://dx.doi.org/10.1007/s00395-018-0679-9
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