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Programmable sequential mutagenesis by inducible Cpf1 crRNA array inversion

Mutations and genetic alterations are often sequentially acquired in various biological and pathological processes, such as development, evolution, and cancer. Certain phenotypes only manifest with precise temporal sequences of genetic events. While multiple approaches have been developed to model t...

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Detalles Bibliográficos
Autores principales: Chow, Ryan D., Kim, Hyunu Ray, Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954137/
https://www.ncbi.nlm.nih.gov/pubmed/29765043
http://dx.doi.org/10.1038/s41467-018-04158-z