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Programmable sequential mutagenesis by inducible Cpf1 crRNA array inversion
Mutations and genetic alterations are often sequentially acquired in various biological and pathological processes, such as development, evolution, and cancer. Certain phenotypes only manifest with precise temporal sequences of genetic events. While multiple approaches have been developed to model t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954137/ https://www.ncbi.nlm.nih.gov/pubmed/29765043 http://dx.doi.org/10.1038/s41467-018-04158-z |